Revision of structures of acridone alkaloids from natural sources

Hung Yi Chen, Sio Hong Lam, Mei Lin Yang, Hsin Yi Hung, Po Chuen Shieh, Fu An Chen, Ping Chung Kuo, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review


The reported chemical structures of tricyclic acridone alkaloids (1–6) from Severinia buxifolia and Pleiospermium alatum were reinvestigated through a comparison of the nuclear magnetic resonance (NMR) spectral data of similar compounds and a comprehensive study of their two-dimensional (2D) NMR spectra. The structures of 1–5 were further confirmed by a comparison of their spectral data with those of the authentic samples and standards. The different chemical shifts caused by substituted functional groups in the tricyclic acridones were summarized according to the results in the present study. Furthermore, the synthetic compound 10 (N-methyl-1,3-dihydroxy-4,5,6-trimethoxyacridine-9-one) has not been reported from any natural sources in the previous literature. In addition, the chemical structures of macranthanine (21) and 7-hydroxy-noracronycine (22) from Glycosmis macrantha were also revised.

Original languageEnglish
JournalJournal of the Chinese Chemical Society
Publication statusAccepted/In press - 2020

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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