Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication

Zhao Hong Li, Chien Ming Li, Pin Ling, Fang Hsiu Shen, Shih Heng Chen, Ching Chuan Liu, Chun Keung Yu, Shun Hua Chen

Research output: Contribution to journalArticlepeer-review

98 Citations (Scopus)

Abstract

Enterovirus 71 (EV71) causes fatal encephalitis in young children. However, there is no effective antiviral drug available for infected patients. Ribavirin is currently used for the treatment of several RNA virus infections clinically, so its anti-EV71 efficacy was evaluated. In vitro results showed that ribavirin effectively reduced the viral yields (with an IC50 of 65 μg/mL) and virus-induced cytopathic effect in human and mouse cell lines. In vivo results showed that ribavirin reduced the mortality, morbidity, and subsequent paralysis sequelae in infected mice by decreasing viral loads in tissues. Thus, ribavirin could be a potential anti-EV71 drug.

Original languageEnglish
Pages (from-to)854-857
Number of pages4
JournalJournal of Infectious Diseases
Volume197
Issue number6
DOIs
Publication statusPublished - 2008 Mar 15

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

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