Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication

Zhao Hong Li; Chien Ming Li; Pin Ling; Fang Hsiu Shen; Shih Heng Chen; Ching Chuan Liu; Chun Keung Yu; Shun Hua Chen

doi:10.1086/527326

Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication

Zhao Hong Li, Chien Ming Li, Pin Ling, Fang Hsiu Shen, Shih Heng Chen, Ching Chuan Liu, Chun Keung Yu, Shun Hua Chen

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98 Citations (Scopus)

Abstract

Enterovirus 71 (EV71) causes fatal encephalitis in young children. However, there is no effective antiviral drug available for infected patients. Ribavirin is currently used for the treatment of several RNA virus infections clinically, so its anti-EV71 efficacy was evaluated. In vitro results showed that ribavirin effectively reduced the viral yields (with an IC₅₀ of 65 μg/mL) and virus-induced cytopathic effect in human and mouse cell lines. In vivo results showed that ribavirin reduced the mortality, morbidity, and subsequent paralysis sequelae in infected mice by decreasing viral loads in tissues. Thus, ribavirin could be a potential anti-EV71 drug.

Original language	English
Pages (from-to)	854-857
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	197
Issue number	6
DOIs	https://doi.org/10.1086/527326
Publication status	Published - 2008 Mar 15

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Infectious Diseases

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10.1086/527326

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title = "Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication",

abstract = "Enterovirus 71 (EV71) causes fatal encephalitis in young children. However, there is no effective antiviral drug available for infected patients. Ribavirin is currently used for the treatment of several RNA virus infections clinically, so its anti-EV71 efficacy was evaluated. In vitro results showed that ribavirin effectively reduced the viral yields (with an IC50 of 65 μg/mL) and virus-induced cytopathic effect in human and mouse cell lines. In vivo results showed that ribavirin reduced the mortality, morbidity, and subsequent paralysis sequelae in infected mice by decreasing viral loads in tissues. Thus, ribavirin could be a potential anti-EV71 drug.",

author = "Li, {Zhao Hong} and Li, {Chien Ming} and Pin Ling and Shen, {Fang Hsiu} and Chen, {Shih Heng} and Liu, {Ching Chuan} and Yu, {Chun Keung} and Chen, {Shun Hua}",

note = "Funding Information: Received 23 August 2007; accepted 6 September 2007; electronically published 15 February 2008. Potential conflicts of interest: none reported. Presented in part: Pasteur/NHRI/CDC Symposium on Re-Emerging Virus Infections, Tainan, Taiwan, 1 September 2006 (abstract POS-17). Financial support: National Health Research Institute, Department of Health, Republic of China (grant NHRI-EX95–9530NI). Reprints or correspondence: Dr. Shun-Hua Chen, Dept. of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan 70101, Republic of China (shunhua@mail.ncku.edu.tw).",

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AU - Li, Zhao Hong

AU - Li, Chien Ming

AU - Ling, Pin

AU - Shen, Fang Hsiu

AU - Chen, Shih Heng

AU - Liu, Ching Chuan

AU - Yu, Chun Keung

AU - Chen, Shun Hua

N1 - Funding Information: Received 23 August 2007; accepted 6 September 2007; electronically published 15 February 2008. Potential conflicts of interest: none reported. Presented in part: Pasteur/NHRI/CDC Symposium on Re-Emerging Virus Infections, Tainan, Taiwan, 1 September 2006 (abstract POS-17). Financial support: National Health Research Institute, Department of Health, Republic of China (grant NHRI-EX95–9530NI). Reprints or correspondence: Dr. Shun-Hua Chen, Dept. of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan 70101, Republic of China (shunhua@mail.ncku.edu.tw).

PY - 2008/3/15

Y1 - 2008/3/15

N2 - Enterovirus 71 (EV71) causes fatal encephalitis in young children. However, there is no effective antiviral drug available for infected patients. Ribavirin is currently used for the treatment of several RNA virus infections clinically, so its anti-EV71 efficacy was evaluated. In vitro results showed that ribavirin effectively reduced the viral yields (with an IC50 of 65 μg/mL) and virus-induced cytopathic effect in human and mouse cell lines. In vivo results showed that ribavirin reduced the mortality, morbidity, and subsequent paralysis sequelae in infected mice by decreasing viral loads in tissues. Thus, ribavirin could be a potential anti-EV71 drug.

AB - Enterovirus 71 (EV71) causes fatal encephalitis in young children. However, there is no effective antiviral drug available for infected patients. Ribavirin is currently used for the treatment of several RNA virus infections clinically, so its anti-EV71 efficacy was evaluated. In vitro results showed that ribavirin effectively reduced the viral yields (with an IC50 of 65 μg/mL) and virus-induced cytopathic effect in human and mouse cell lines. In vivo results showed that ribavirin reduced the mortality, morbidity, and subsequent paralysis sequelae in infected mice by decreasing viral loads in tissues. Thus, ribavirin could be a potential anti-EV71 drug.

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Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication

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