Risk factors for a first febrile convulsion in children

A population study in southern Taiwan

Chao-Ching Huang, Shan-Tair Wang, Ying Chao Chang, Mei-Chih Huang, Yun-Chan Chi, Jing Jane Tsai

Research output: Contribution to journalArticle

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Abstract

Purpose: To identify risk factors for a first febrile convulsion among 3-year-old children by a matched case-control population study. Methods: All 11,714 neonatal survivors born in Tainan City between October 1989 and September 1991 were enrolled. At age 3, 10,460 children were available for telephone survey for febrile convulsions, and were confirmed by home visit interviews. Those without history of seizure were randomly matched to each febrile convulsion case by age, gender, and residence district. Results: Two hundred fifty six children had febrile convulsions, and 218 of them and their matched controls were available for analysis. The febrile convulsion cases had significantly more febrile episodes (four or more) per year (33.0 vs. 22.5%; p = 0.021), and cases had a higher percentage of developmental delay (3.7 vs. 0.4%; p = 0.046) and a higher percentage of febrile convulsions in their siblings (12 vs. 0.4%; p = 0.011) than controls. The other sociodemographic, environmental, and biologic variables showed no differences between cases and controls. Step-wise logistic regression showed a highly significant independent association between febrile convulsions and history of febrile convulsions in the siblings, and a moderate one between febrile convulsions and the number of febrile episodes per year. Conclusions: The presence of febrile convulsions in the siblings and the number of fever episodes per year were the independent and significant predictors of febrile convulsion for an individual case in our population-based sample.

Original languageEnglish
Pages (from-to)719-725
Number of pages7
JournalEpilepsia
Volume40
Issue number6
DOIs
Publication statusPublished - 1999 Jun 15

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Febrile Seizures
Taiwan
Population
Siblings
Fever
House Calls
Telephone
Survivors
Case-Control Studies
Seizures
Logistic Models
Interviews

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

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title = "Risk factors for a first febrile convulsion in children: A population study in southern Taiwan",
abstract = "Purpose: To identify risk factors for a first febrile convulsion among 3-year-old children by a matched case-control population study. Methods: All 11,714 neonatal survivors born in Tainan City between October 1989 and September 1991 were enrolled. At age 3, 10,460 children were available for telephone survey for febrile convulsions, and were confirmed by home visit interviews. Those without history of seizure were randomly matched to each febrile convulsion case by age, gender, and residence district. Results: Two hundred fifty six children had febrile convulsions, and 218 of them and their matched controls were available for analysis. The febrile convulsion cases had significantly more febrile episodes (four or more) per year (33.0 vs. 22.5{\%}; p = 0.021), and cases had a higher percentage of developmental delay (3.7 vs. 0.4{\%}; p = 0.046) and a higher percentage of febrile convulsions in their siblings (12 vs. 0.4{\%}; p = 0.011) than controls. The other sociodemographic, environmental, and biologic variables showed no differences between cases and controls. Step-wise logistic regression showed a highly significant independent association between febrile convulsions and history of febrile convulsions in the siblings, and a moderate one between febrile convulsions and the number of febrile episodes per year. Conclusions: The presence of febrile convulsions in the siblings and the number of fever episodes per year were the independent and significant predictors of febrile convulsion for an individual case in our population-based sample.",
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Risk factors for a first febrile convulsion in children : A population study in southern Taiwan. / Huang, Chao-Ching; Wang, Shan-Tair; Chang, Ying Chao; Huang, Mei-Chih; Chi, Yun-Chan; Tsai, Jing Jane.

In: Epilepsia, Vol. 40, No. 6, 15.06.1999, p. 719-725.

Research output: Contribution to journalArticle

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T1 - Risk factors for a first febrile convulsion in children

T2 - A population study in southern Taiwan

AU - Huang, Chao-Ching

AU - Wang, Shan-Tair

AU - Chang, Ying Chao

AU - Huang, Mei-Chih

AU - Chi, Yun-Chan

AU - Tsai, Jing Jane

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Y1 - 1999/6/15

N2 - Purpose: To identify risk factors for a first febrile convulsion among 3-year-old children by a matched case-control population study. Methods: All 11,714 neonatal survivors born in Tainan City between October 1989 and September 1991 were enrolled. At age 3, 10,460 children were available for telephone survey for febrile convulsions, and were confirmed by home visit interviews. Those without history of seizure were randomly matched to each febrile convulsion case by age, gender, and residence district. Results: Two hundred fifty six children had febrile convulsions, and 218 of them and their matched controls were available for analysis. The febrile convulsion cases had significantly more febrile episodes (four or more) per year (33.0 vs. 22.5%; p = 0.021), and cases had a higher percentage of developmental delay (3.7 vs. 0.4%; p = 0.046) and a higher percentage of febrile convulsions in their siblings (12 vs. 0.4%; p = 0.011) than controls. The other sociodemographic, environmental, and biologic variables showed no differences between cases and controls. Step-wise logistic regression showed a highly significant independent association between febrile convulsions and history of febrile convulsions in the siblings, and a moderate one between febrile convulsions and the number of febrile episodes per year. Conclusions: The presence of febrile convulsions in the siblings and the number of fever episodes per year were the independent and significant predictors of febrile convulsion for an individual case in our population-based sample.

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