Risk of hand syndromes in patients with diabetes mellitus

A population-based cohort study in Taiwan

Lu Hsuan Chen, Chung-Yi Li, Li-Chieh Kuo, Liang-Yi Wang, Ken N. Kuo, I. Ming Jou, Wen Hsuan Hou

Research output: Contribution to journalArticle

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Abstract

The aim of this study was to assess the overall and causespecific incidences of diabetic hand syndromes (DHS) in patients with diabetes mellitus (DM) by using age and sex stratifications. The DM and control cohorts comprised 606,152 patients with DM and 609,970 age-and sex-matched subjects, respectively, who were followed up from 2000 to 2008. We estimated the incidence densities (IDs) of overall and cause-specific DHS, namely carpal tunnel syndrome (CTS), stenosing flexor tenosynovitis (SFT), limited joint mobility (LJM), and Dupuytren disease (DD), and calculated the hazard ratios (HRs) of DHS in relation to DM by using a Cox proportional hazards model with adjustment for potential confounders. Over a 9-year period, 51,207 patients with DM (8.45%) and 39,153 matched controls (6.42%) sought ambulatory care visits for various DHS, with an ID of 117.7 and 80.7 per 10,000 person-years, respectively. The highest cause-specific ID was observed for CTS, followed by SFT, LJM, and DD, regardless of the diabetic status. After adjustment for potential confounders, patients with DM had a significantly high HR of overall DHS (1.51, 95% confidence interval [CI]=1.48-1.53). Men and women aged <35 years had the highest HR (2.64, 95% CI=2.15- 3.24 and 2.99, 95% CI=2.55-3.50, respectively). Cause-specific analyses revealed that DM was more strongly associated with SFT (HR=1.90, 95% CI=1.86-1.95) and DD (HR=1.83, 95% CI=1.39- 2.39) than with CTS (HR=1.31, 95% CI=1.28-1.34) and LJM (HR=1.24, 95% CI=1.13-1.35). Men and younger patients with DM have the highest risk of DHS. Certain hand syndromes, such as SFT and DD, were more strongly associated with DM than with other syndromes and require the attention of clinicians.

Original languageEnglish
Article numbere1575
JournalMedicine (United States)
Volume94
Issue number41
DOIs
Publication statusPublished - 2015 Jan 1

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Taiwan
Diabetes Mellitus
Cohort Studies
Hand
Tendon Entrapment
Dupuytren Contracture
Confidence Intervals
Population
Carpal Tunnel Syndrome
Joint Diseases
Incidence
Ambulatory Care
Proportional Hazards Models
Joints

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{9b7716ec5f1d48be8bed494a4710f66b,
title = "Risk of hand syndromes in patients with diabetes mellitus: A population-based cohort study in Taiwan",
abstract = "The aim of this study was to assess the overall and causespecific incidences of diabetic hand syndromes (DHS) in patients with diabetes mellitus (DM) by using age and sex stratifications. The DM and control cohorts comprised 606,152 patients with DM and 609,970 age-and sex-matched subjects, respectively, who were followed up from 2000 to 2008. We estimated the incidence densities (IDs) of overall and cause-specific DHS, namely carpal tunnel syndrome (CTS), stenosing flexor tenosynovitis (SFT), limited joint mobility (LJM), and Dupuytren disease (DD), and calculated the hazard ratios (HRs) of DHS in relation to DM by using a Cox proportional hazards model with adjustment for potential confounders. Over a 9-year period, 51,207 patients with DM (8.45{\%}) and 39,153 matched controls (6.42{\%}) sought ambulatory care visits for various DHS, with an ID of 117.7 and 80.7 per 10,000 person-years, respectively. The highest cause-specific ID was observed for CTS, followed by SFT, LJM, and DD, regardless of the diabetic status. After adjustment for potential confounders, patients with DM had a significantly high HR of overall DHS (1.51, 95{\%} confidence interval [CI]=1.48-1.53). Men and women aged <35 years had the highest HR (2.64, 95{\%} CI=2.15- 3.24 and 2.99, 95{\%} CI=2.55-3.50, respectively). Cause-specific analyses revealed that DM was more strongly associated with SFT (HR=1.90, 95{\%} CI=1.86-1.95) and DD (HR=1.83, 95{\%} CI=1.39- 2.39) than with CTS (HR=1.31, 95{\%} CI=1.28-1.34) and LJM (HR=1.24, 95{\%} CI=1.13-1.35). Men and younger patients with DM have the highest risk of DHS. Certain hand syndromes, such as SFT and DD, were more strongly associated with DM than with other syndromes and require the attention of clinicians.",
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Risk of hand syndromes in patients with diabetes mellitus : A population-based cohort study in Taiwan. / Chen, Lu Hsuan; Li, Chung-Yi; Kuo, Li-Chieh; Wang, Liang-Yi; Kuo, Ken N.; Jou, I. Ming; Hou, Wen Hsuan.

In: Medicine (United States), Vol. 94, No. 41, e1575, 01.01.2015.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Risk of hand syndromes in patients with diabetes mellitus

T2 - A population-based cohort study in Taiwan

AU - Chen, Lu Hsuan

AU - Li, Chung-Yi

AU - Kuo, Li-Chieh

AU - Wang, Liang-Yi

AU - Kuo, Ken N.

AU - Jou, I. Ming

AU - Hou, Wen Hsuan

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N2 - The aim of this study was to assess the overall and causespecific incidences of diabetic hand syndromes (DHS) in patients with diabetes mellitus (DM) by using age and sex stratifications. The DM and control cohorts comprised 606,152 patients with DM and 609,970 age-and sex-matched subjects, respectively, who were followed up from 2000 to 2008. We estimated the incidence densities (IDs) of overall and cause-specific DHS, namely carpal tunnel syndrome (CTS), stenosing flexor tenosynovitis (SFT), limited joint mobility (LJM), and Dupuytren disease (DD), and calculated the hazard ratios (HRs) of DHS in relation to DM by using a Cox proportional hazards model with adjustment for potential confounders. Over a 9-year period, 51,207 patients with DM (8.45%) and 39,153 matched controls (6.42%) sought ambulatory care visits for various DHS, with an ID of 117.7 and 80.7 per 10,000 person-years, respectively. The highest cause-specific ID was observed for CTS, followed by SFT, LJM, and DD, regardless of the diabetic status. After adjustment for potential confounders, patients with DM had a significantly high HR of overall DHS (1.51, 95% confidence interval [CI]=1.48-1.53). Men and women aged <35 years had the highest HR (2.64, 95% CI=2.15- 3.24 and 2.99, 95% CI=2.55-3.50, respectively). Cause-specific analyses revealed that DM was more strongly associated with SFT (HR=1.90, 95% CI=1.86-1.95) and DD (HR=1.83, 95% CI=1.39- 2.39) than with CTS (HR=1.31, 95% CI=1.28-1.34) and LJM (HR=1.24, 95% CI=1.13-1.35). Men and younger patients with DM have the highest risk of DHS. Certain hand syndromes, such as SFT and DD, were more strongly associated with DM than with other syndromes and require the attention of clinicians.

AB - The aim of this study was to assess the overall and causespecific incidences of diabetic hand syndromes (DHS) in patients with diabetes mellitus (DM) by using age and sex stratifications. The DM and control cohorts comprised 606,152 patients with DM and 609,970 age-and sex-matched subjects, respectively, who were followed up from 2000 to 2008. We estimated the incidence densities (IDs) of overall and cause-specific DHS, namely carpal tunnel syndrome (CTS), stenosing flexor tenosynovitis (SFT), limited joint mobility (LJM), and Dupuytren disease (DD), and calculated the hazard ratios (HRs) of DHS in relation to DM by using a Cox proportional hazards model with adjustment for potential confounders. Over a 9-year period, 51,207 patients with DM (8.45%) and 39,153 matched controls (6.42%) sought ambulatory care visits for various DHS, with an ID of 117.7 and 80.7 per 10,000 person-years, respectively. The highest cause-specific ID was observed for CTS, followed by SFT, LJM, and DD, regardless of the diabetic status. After adjustment for potential confounders, patients with DM had a significantly high HR of overall DHS (1.51, 95% confidence interval [CI]=1.48-1.53). Men and women aged <35 years had the highest HR (2.64, 95% CI=2.15- 3.24 and 2.99, 95% CI=2.55-3.50, respectively). Cause-specific analyses revealed that DM was more strongly associated with SFT (HR=1.90, 95% CI=1.86-1.95) and DD (HR=1.83, 95% CI=1.39- 2.39) than with CTS (HR=1.31, 95% CI=1.28-1.34) and LJM (HR=1.24, 95% CI=1.13-1.35). Men and younger patients with DM have the highest risk of DHS. Certain hand syndromes, such as SFT and DD, were more strongly associated with DM than with other syndromes and require the attention of clinicians.

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