Risk of secondary cancers in women with breast cancer and the influence of radiotherapy A national cohort study in Taiwan

Cheng Yao Lin, Sih Hao Chen, Chien Cheng Huang, Shih Feng Weng, Song Tay Lee, How-Ran Guo, Shu Chun Kuo, Shih Bin Su

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Abstract

Breast cancer is the most common cancer in women worldwide; thus, the prolongation of survival, and the incidence and risk factors, including radiotherapy, for developing secondary malignancies are important. We compared the incidence of secondary and new primary cancers in women with breast cancer (CAPos) and well-matched for age, geographic region, and monthly income cancer-free controls (CANeg). The risk for secondary cancers with and without radiotherapy was also compared in CAPos women. We enrolled 2422 CAPos patients and CANeg 12,110 controls. In a 4-year follow-up, the secondary cancers risk was significant in the CAPos group (adjusted hazard ratio [AHR]: 1.59; 95% confidence interval [CI]: 1.17-2.18). Only the risk of uterine cancer was significant compared with the controls (AHR: 6.30; 95% CI: 2.28-17.38). CAPos patients and <50 years old had a higher risk for secondary cancers. Developing secondary cancers was significant in the first follow-up year (AHR: 1.51; 95% CI: 1.11-2.06). Radiotherapy had no significant effect on the CAPos group, but it was significant (P=0.0298) in women =60 years old (elderly). We recommend monitoring secondary cancers in CAPos women, especially those <50 years old, and during the first year of follow-up. Radiotherapy should be used more carefully in elderly CAPos women.

Original languageEnglish
Pages (from-to)e5556
JournalMedicine (United States)
Volume95
Issue number49
DOIs
Publication statusPublished - 2016 Jan 1

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Taiwan
Cohort Studies
Radiotherapy
Breast Neoplasms
Neoplasms
Confidence Intervals
Safety Management
Uterine Neoplasms
Incidence
Survival

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lin, Cheng Yao ; Chen, Sih Hao ; Huang, Chien Cheng ; Weng, Shih Feng ; Lee, Song Tay ; Guo, How-Ran ; Kuo, Shu Chun ; Su, Shih Bin. / Risk of secondary cancers in women with breast cancer and the influence of radiotherapy A national cohort study in Taiwan. In: Medicine (United States). 2016 ; Vol. 95, No. 49. pp. e5556.
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Risk of secondary cancers in women with breast cancer and the influence of radiotherapy A national cohort study in Taiwan. / Lin, Cheng Yao; Chen, Sih Hao; Huang, Chien Cheng; Weng, Shih Feng; Lee, Song Tay; Guo, How-Ran; Kuo, Shu Chun; Su, Shih Bin.

In: Medicine (United States), Vol. 95, No. 49, 01.01.2016, p. e5556.

Research output: Contribution to journalArticle

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