TY - JOUR
T1 - Risks of anxiety disorders, depressive disorders, and sleep disorders in patients with dengue fever
T2 - A nationwide, population-based cohort study
AU - Shih, Hsin I.
AU - Wang, Yu Ping
AU - Chi, Chia Yu
AU - Chien, Yu Wen
N1 - Publisher Copyright:
© 2024 Shih et al.
PY - 2024/7
Y1 - 2024/7
N2 - Background Dengue virus (DENV) infection, a common mosquito-borne disease, has been linked to sev-eral mental disorders like depression and anxiety. However, the temporal risk of these disorders after DENV infection is not well studied. Methods This population-based cohort study encompassed 45,334 recently lab-confirmed dengue patients in Taiwan spanning 2002 to 2015, matched at a 1:5 ratio with non-dengue individuals based on age, gender, and residence (n = 226,670). Employing subdistribution hazard regression analysis, we assessed the immediate (<3 months), intermediate (3–12 months), and prolonged (>12 months) risks of anxiety disorders, depressive disorders, and sleep disorders post DENV infection. Corrections for multiple comparisons were carried out using the Benjamini-Hochberg procedure. Results A significant increase in depressive disorder risk across all timeframes post-infection was observed (<3 months [aSHR 1.90, 95% CI 1.20–2.99], 3–12 months [aSHR 1.68, 95% CI 1.32–2.14], and >12 months [aSHR 1.14, 95% CI 1.03–1.25]). Sleep disorder risk was higher only during 3–12 months (aSHR 1.55, 95% CI 1.18–2.04). No elevated anxiety disorder risk was found. Subgroup analysis of hospitalized dengue patients showed increased risk of anxiety disorders within 3 months (aSHR 2.14, 95% CI 1.19–3.85) and persistent risk of depressive disorders across all periods. Hospitalized dengue patients also had elevated sleep disorder risk within the first year. Conclusion Dengue patients exhibited significantly elevated risks of depressive disorders in both the short and long term. However, dengue’s impact on sleep disorders and anxiety seems to be short-lived. Further research is essential to elucidate the underlying mechanisms.
AB - Background Dengue virus (DENV) infection, a common mosquito-borne disease, has been linked to sev-eral mental disorders like depression and anxiety. However, the temporal risk of these disorders after DENV infection is not well studied. Methods This population-based cohort study encompassed 45,334 recently lab-confirmed dengue patients in Taiwan spanning 2002 to 2015, matched at a 1:5 ratio with non-dengue individuals based on age, gender, and residence (n = 226,670). Employing subdistribution hazard regression analysis, we assessed the immediate (<3 months), intermediate (3–12 months), and prolonged (>12 months) risks of anxiety disorders, depressive disorders, and sleep disorders post DENV infection. Corrections for multiple comparisons were carried out using the Benjamini-Hochberg procedure. Results A significant increase in depressive disorder risk across all timeframes post-infection was observed (<3 months [aSHR 1.90, 95% CI 1.20–2.99], 3–12 months [aSHR 1.68, 95% CI 1.32–2.14], and >12 months [aSHR 1.14, 95% CI 1.03–1.25]). Sleep disorder risk was higher only during 3–12 months (aSHR 1.55, 95% CI 1.18–2.04). No elevated anxiety disorder risk was found. Subgroup analysis of hospitalized dengue patients showed increased risk of anxiety disorders within 3 months (aSHR 2.14, 95% CI 1.19–3.85) and persistent risk of depressive disorders across all periods. Hospitalized dengue patients also had elevated sleep disorder risk within the first year. Conclusion Dengue patients exhibited significantly elevated risks of depressive disorders in both the short and long term. However, dengue’s impact on sleep disorders and anxiety seems to be short-lived. Further research is essential to elucidate the underlying mechanisms.
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U2 - 10.1371/journal.pntd.0012239
DO - 10.1371/journal.pntd.0012239
M3 - Article
C2 - 38959212
AN - SCOPUS:85197685913
SN - 1935-2727
VL - 18
JO - PLoS neglected tropical diseases
JF - PLoS neglected tropical diseases
IS - 7
M1 - e0012239
ER -