Risks of bipolar disorder, depressive disorder, and traumatic brain injury among siblings of patients with attention-deficit hyperactivity disorder

Han Ting Wei, Tai Long Pan, Ju Wei Hsu, Kai Lin Huang, Ya Mei Bai, Nai-Ying Ko, Tung Ping Su, Cheng Ta Li, Shih Jen Tsai, Wei Chen Lin, Tzeng Ji Chen, Mu Hong Chen

Research output: Contribution to journalArticle

Abstract

Background: Previous studies have suggested that the unaffected siblings of patients with attention-deficit hyperactivity disorder (ADHD) experience deficits in attention, impulsivity control, and behavior inhibition, which are associated with health-risk behaviors. However, risks to mental and physical health among the unaffected siblings of ADHD probands have rarely been investigated. Methods: Using the Taiwan National Health Insurance Research Database, 5128 unaffected siblings of ADHD probands born between 1980 and 2000 were included in our study along with 20,512 age- and sex-matched controls, and they were followed from 1996 or birth until the end of 2011. Mental and physical health risks, including affective disorders, traumatic brain injury (TBI), and sexually transmitted infection were identified during the follow-up period. Results: Logistic regression analyses with adjustments for demographic data showed that the unaffected siblings were more likely to develop unipolar depression (odds ratio [OR]: 1.76, 95% confidence interval [CI]: 1.39–2.22), bipolar disorder (OR: 2.10, 95% CI: 1. 09–4.05), and TBI (OR: 1.24, 95% CI: 1.14–1.36) than were the control group. Discussion: The unaffected siblings of patients with ADHD were prone to developing unipolar depression, bipolar disorder, and TBI later in life.

LanguageEnglish
Pages335-339
Number of pages5
JournalJournal of Affective Disorders
Volume245
DOIs
Publication statusPublished - 2019 Feb 15

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Attention Deficit Disorder with Hyperactivity
Depressive Disorder
Bipolar Disorder
Siblings
Odds Ratio
Confidence Intervals
Mental Health
Behavior Control
Impulsive Behavior
National Health Programs
Sexually Transmitted Diseases
Risk-Taking
Mood Disorders
Taiwan
Research Design
Logistic Models
Regression Analysis
Demography
Traumatic Brain Injury
Parturition

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Wei, Han Ting ; Pan, Tai Long ; Hsu, Ju Wei ; Huang, Kai Lin ; Bai, Ya Mei ; Ko, Nai-Ying ; Su, Tung Ping ; Li, Cheng Ta ; Tsai, Shih Jen ; Lin, Wei Chen ; Chen, Tzeng Ji ; Chen, Mu Hong. / Risks of bipolar disorder, depressive disorder, and traumatic brain injury among siblings of patients with attention-deficit hyperactivity disorder. In: Journal of Affective Disorders. 2019 ; Vol. 245. pp. 335-339.
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abstract = "Background: Previous studies have suggested that the unaffected siblings of patients with attention-deficit hyperactivity disorder (ADHD) experience deficits in attention, impulsivity control, and behavior inhibition, which are associated with health-risk behaviors. However, risks to mental and physical health among the unaffected siblings of ADHD probands have rarely been investigated. Methods: Using the Taiwan National Health Insurance Research Database, 5128 unaffected siblings of ADHD probands born between 1980 and 2000 were included in our study along with 20,512 age- and sex-matched controls, and they were followed from 1996 or birth until the end of 2011. Mental and physical health risks, including affective disorders, traumatic brain injury (TBI), and sexually transmitted infection were identified during the follow-up period. Results: Logistic regression analyses with adjustments for demographic data showed that the unaffected siblings were more likely to develop unipolar depression (odds ratio [OR]: 1.76, 95{\%} confidence interval [CI]: 1.39–2.22), bipolar disorder (OR: 2.10, 95{\%} CI: 1. 09–4.05), and TBI (OR: 1.24, 95{\%} CI: 1.14–1.36) than were the control group. Discussion: The unaffected siblings of patients with ADHD were prone to developing unipolar depression, bipolar disorder, and TBI later in life.",
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Risks of bipolar disorder, depressive disorder, and traumatic brain injury among siblings of patients with attention-deficit hyperactivity disorder. / Wei, Han Ting; Pan, Tai Long; Hsu, Ju Wei; Huang, Kai Lin; Bai, Ya Mei; Ko, Nai-Ying; Su, Tung Ping; Li, Cheng Ta; Tsai, Shih Jen; Lin, Wei Chen; Chen, Tzeng Ji; Chen, Mu Hong.

In: Journal of Affective Disorders, Vol. 245, 15.02.2019, p. 335-339.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Risks of bipolar disorder, depressive disorder, and traumatic brain injury among siblings of patients with attention-deficit hyperactivity disorder

AU - Wei, Han Ting

AU - Pan, Tai Long

AU - Hsu, Ju Wei

AU - Huang, Kai Lin

AU - Bai, Ya Mei

AU - Ko, Nai-Ying

AU - Su, Tung Ping

AU - Li, Cheng Ta

AU - Tsai, Shih Jen

AU - Lin, Wei Chen

AU - Chen, Tzeng Ji

AU - Chen, Mu Hong

PY - 2019/2/15

Y1 - 2019/2/15

N2 - Background: Previous studies have suggested that the unaffected siblings of patients with attention-deficit hyperactivity disorder (ADHD) experience deficits in attention, impulsivity control, and behavior inhibition, which are associated with health-risk behaviors. However, risks to mental and physical health among the unaffected siblings of ADHD probands have rarely been investigated. Methods: Using the Taiwan National Health Insurance Research Database, 5128 unaffected siblings of ADHD probands born between 1980 and 2000 were included in our study along with 20,512 age- and sex-matched controls, and they were followed from 1996 or birth until the end of 2011. Mental and physical health risks, including affective disorders, traumatic brain injury (TBI), and sexually transmitted infection were identified during the follow-up period. Results: Logistic regression analyses with adjustments for demographic data showed that the unaffected siblings were more likely to develop unipolar depression (odds ratio [OR]: 1.76, 95% confidence interval [CI]: 1.39–2.22), bipolar disorder (OR: 2.10, 95% CI: 1. 09–4.05), and TBI (OR: 1.24, 95% CI: 1.14–1.36) than were the control group. Discussion: The unaffected siblings of patients with ADHD were prone to developing unipolar depression, bipolar disorder, and TBI later in life.

AB - Background: Previous studies have suggested that the unaffected siblings of patients with attention-deficit hyperactivity disorder (ADHD) experience deficits in attention, impulsivity control, and behavior inhibition, which are associated with health-risk behaviors. However, risks to mental and physical health among the unaffected siblings of ADHD probands have rarely been investigated. Methods: Using the Taiwan National Health Insurance Research Database, 5128 unaffected siblings of ADHD probands born between 1980 and 2000 were included in our study along with 20,512 age- and sex-matched controls, and they were followed from 1996 or birth until the end of 2011. Mental and physical health risks, including affective disorders, traumatic brain injury (TBI), and sexually transmitted infection were identified during the follow-up period. Results: Logistic regression analyses with adjustments for demographic data showed that the unaffected siblings were more likely to develop unipolar depression (odds ratio [OR]: 1.76, 95% confidence interval [CI]: 1.39–2.22), bipolar disorder (OR: 2.10, 95% CI: 1. 09–4.05), and TBI (OR: 1.24, 95% CI: 1.14–1.36) than were the control group. Discussion: The unaffected siblings of patients with ADHD were prone to developing unipolar depression, bipolar disorder, and TBI later in life.

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