Risks of interstitial cystitis among patients with systemic lupus erythematosus: A population-based cohort study

Jen Yu Wen, Tsia Shu Lo, Yao Chi Chuang, Chung Han Ho, Cheng Yu Long, Kim Seng Law, Yat Ching Tong, Ming Ping Wu

Research output: Contribution to journalArticle

Abstract

Objective: To investigate whether the risk of interstitial cystitis increases among the patients with systemic lupus erythematosus. Methods: This was a nationwide population-based cohort study. Data were obtained from the National Health Insurance Research Database in Taiwan. Women aged >18 years newly diagnosed as systemic lupus erythematosus during 2001–2008 were identified as the control group. The comparison included individuals randomly selected from the National Health Insurance Research Database in the year of 2000, by matching one systemic lupus erythematosus participant with eight non-systemic lupus erythematosus participants with sex and age. These participants were followed up until being diagnosed as interstitial cystitis, or the end of 2011. Women diagnosed with lupus cystitis were excluded from this study. Results: This study included 7240 women with systemic lupus erythematosus and 57 920 women without systemic lupus erythematosus as controls. The incidence rate of interstitial cystitis was significantly higher in the systemic lupus erythematosus group, with an incidence rate ratio of 2.26 (95% confidence interval 1.57–3.27, P < 0.0001). After adjustment, the risk increased by 2.45-fold (adjusted hazard ratio 2.45, 95% confidence interval 1.57–3.27, P < 0.05). Age as a factor increases incidence rate ratios among all age groups, 2.12-, 3.32- and 4.65-fold. Age ≥45 years had an increased adjusted hazard ratio (2.07, 95% confidence interval 1.37–3.13, P < 0.05). Comorbidities, for example, hypertension, diabetes mellitus, dyslipidemia and renal disease, were insignificant. Conclusions: This is the first population-based cohort study showing a higher incidence of interstitial cystitis among patients with systemic lupus erythematosus. These findings support the concordance of interstitial cystitis with autoimmune diseases, and the temporal relationship to develop interstitial cystitis in patients with systemic lupus erythematosus.

Original languageEnglish
Pages (from-to)897-902
Number of pages6
JournalInternational Journal of Urology
Volume26
Issue number9
DOIs
Publication statusPublished - 2019 Sep 1

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Interstitial Cystitis
Systemic Lupus Erythematosus
Cohort Studies
Population
Incidence
National Health Programs
Confidence Intervals
Databases
Cystitis
Dyslipidemias
Taiwan
Research
Autoimmune Diseases
Comorbidity
Diabetes Mellitus
Age Groups
Hypertension
Kidney
Control Groups

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Wen, Jen Yu ; Lo, Tsia Shu ; Chuang, Yao Chi ; Ho, Chung Han ; Long, Cheng Yu ; Law, Kim Seng ; Tong, Yat Ching ; Wu, Ming Ping. / Risks of interstitial cystitis among patients with systemic lupus erythematosus : A population-based cohort study. In: International Journal of Urology. 2019 ; Vol. 26, No. 9. pp. 897-902.
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title = "Risks of interstitial cystitis among patients with systemic lupus erythematosus: A population-based cohort study",
abstract = "Objective: To investigate whether the risk of interstitial cystitis increases among the patients with systemic lupus erythematosus. Methods: This was a nationwide population-based cohort study. Data were obtained from the National Health Insurance Research Database in Taiwan. Women aged >18 years newly diagnosed as systemic lupus erythematosus during 2001–2008 were identified as the control group. The comparison included individuals randomly selected from the National Health Insurance Research Database in the year of 2000, by matching one systemic lupus erythematosus participant with eight non-systemic lupus erythematosus participants with sex and age. These participants were followed up until being diagnosed as interstitial cystitis, or the end of 2011. Women diagnosed with lupus cystitis were excluded from this study. Results: This study included 7240 women with systemic lupus erythematosus and 57 920 women without systemic lupus erythematosus as controls. The incidence rate of interstitial cystitis was significantly higher in the systemic lupus erythematosus group, with an incidence rate ratio of 2.26 (95{\%} confidence interval 1.57–3.27, P < 0.0001). After adjustment, the risk increased by 2.45-fold (adjusted hazard ratio 2.45, 95{\%} confidence interval 1.57–3.27, P < 0.05). Age as a factor increases incidence rate ratios among all age groups, 2.12-, 3.32- and 4.65-fold. Age ≥45 years had an increased adjusted hazard ratio (2.07, 95{\%} confidence interval 1.37–3.13, P < 0.05). Comorbidities, for example, hypertension, diabetes mellitus, dyslipidemia and renal disease, were insignificant. Conclusions: This is the first population-based cohort study showing a higher incidence of interstitial cystitis among patients with systemic lupus erythematosus. These findings support the concordance of interstitial cystitis with autoimmune diseases, and the temporal relationship to develop interstitial cystitis in patients with systemic lupus erythematosus.",
author = "Wen, {Jen Yu} and Lo, {Tsia Shu} and Chuang, {Yao Chi} and Ho, {Chung Han} and Long, {Cheng Yu} and Law, {Kim Seng} and Tong, {Yat Ching} and Wu, {Ming Ping}",
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Risks of interstitial cystitis among patients with systemic lupus erythematosus : A population-based cohort study. / Wen, Jen Yu; Lo, Tsia Shu; Chuang, Yao Chi; Ho, Chung Han; Long, Cheng Yu; Law, Kim Seng; Tong, Yat Ching; Wu, Ming Ping.

In: International Journal of Urology, Vol. 26, No. 9, 01.09.2019, p. 897-902.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Risks of interstitial cystitis among patients with systemic lupus erythematosus

T2 - A population-based cohort study

AU - Wen, Jen Yu

AU - Lo, Tsia Shu

AU - Chuang, Yao Chi

AU - Ho, Chung Han

AU - Long, Cheng Yu

AU - Law, Kim Seng

AU - Tong, Yat Ching

AU - Wu, Ming Ping

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Objective: To investigate whether the risk of interstitial cystitis increases among the patients with systemic lupus erythematosus. Methods: This was a nationwide population-based cohort study. Data were obtained from the National Health Insurance Research Database in Taiwan. Women aged >18 years newly diagnosed as systemic lupus erythematosus during 2001–2008 were identified as the control group. The comparison included individuals randomly selected from the National Health Insurance Research Database in the year of 2000, by matching one systemic lupus erythematosus participant with eight non-systemic lupus erythematosus participants with sex and age. These participants were followed up until being diagnosed as interstitial cystitis, or the end of 2011. Women diagnosed with lupus cystitis were excluded from this study. Results: This study included 7240 women with systemic lupus erythematosus and 57 920 women without systemic lupus erythematosus as controls. The incidence rate of interstitial cystitis was significantly higher in the systemic lupus erythematosus group, with an incidence rate ratio of 2.26 (95% confidence interval 1.57–3.27, P < 0.0001). After adjustment, the risk increased by 2.45-fold (adjusted hazard ratio 2.45, 95% confidence interval 1.57–3.27, P < 0.05). Age as a factor increases incidence rate ratios among all age groups, 2.12-, 3.32- and 4.65-fold. Age ≥45 years had an increased adjusted hazard ratio (2.07, 95% confidence interval 1.37–3.13, P < 0.05). Comorbidities, for example, hypertension, diabetes mellitus, dyslipidemia and renal disease, were insignificant. Conclusions: This is the first population-based cohort study showing a higher incidence of interstitial cystitis among patients with systemic lupus erythematosus. These findings support the concordance of interstitial cystitis with autoimmune diseases, and the temporal relationship to develop interstitial cystitis in patients with systemic lupus erythematosus.

AB - Objective: To investigate whether the risk of interstitial cystitis increases among the patients with systemic lupus erythematosus. Methods: This was a nationwide population-based cohort study. Data were obtained from the National Health Insurance Research Database in Taiwan. Women aged >18 years newly diagnosed as systemic lupus erythematosus during 2001–2008 were identified as the control group. The comparison included individuals randomly selected from the National Health Insurance Research Database in the year of 2000, by matching one systemic lupus erythematosus participant with eight non-systemic lupus erythematosus participants with sex and age. These participants were followed up until being diagnosed as interstitial cystitis, or the end of 2011. Women diagnosed with lupus cystitis were excluded from this study. Results: This study included 7240 women with systemic lupus erythematosus and 57 920 women without systemic lupus erythematosus as controls. The incidence rate of interstitial cystitis was significantly higher in the systemic lupus erythematosus group, with an incidence rate ratio of 2.26 (95% confidence interval 1.57–3.27, P < 0.0001). After adjustment, the risk increased by 2.45-fold (adjusted hazard ratio 2.45, 95% confidence interval 1.57–3.27, P < 0.05). Age as a factor increases incidence rate ratios among all age groups, 2.12-, 3.32- and 4.65-fold. Age ≥45 years had an increased adjusted hazard ratio (2.07, 95% confidence interval 1.37–3.13, P < 0.05). Comorbidities, for example, hypertension, diabetes mellitus, dyslipidemia and renal disease, were insignificant. Conclusions: This is the first population-based cohort study showing a higher incidence of interstitial cystitis among patients with systemic lupus erythematosus. These findings support the concordance of interstitial cystitis with autoimmune diseases, and the temporal relationship to develop interstitial cystitis in patients with systemic lupus erythematosus.

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