Objectives: To assess the association between roadway density and the incidence of hypertension and to evaluate the role of fine particulate matter (PM23) on that association by using mediation analyses Methods: Wc included participants' health information retrieved from the Longitudinal Health Insurance Database 2000. We retrieved roadway density (e.g. county road) from the Institute of Transportation's Digital Road Network Map 2006. Participants' long-Term exposure to traffic-related pollution was based on the roadway density of the township in which they resided. We applied Cox proportional hazards models to assess the association between the incidence of hypertension and road density. Casual mediation models were utilized to estimate the mediation effect of PMJ3 on the roadway density-hypertension association. Results: During a median follow-up time of 11.01 years. 108.733 cases of hypertension were identified. After we controlled for potential confounders, participants who resided in townships with a higher density of county roads (i 139 m/m1) had a 17% higher risk for hypertension when compared to the reference group (Hazard Ratio [HR)=1.17; 95% Confidence Intervals [CIsJ: 1.14-1.19), and similar results were also found for country roads (HR=I.09. 95% CIs: 1.07-1.10). Results were not materially different when we included only participants who lived in a metropolitan area (e.g. Taipei city). Furthermore, PM2J imposed a statistically significant mediating effect on the incidence of roadway density-Associated hypertension for county roadway exposure (HR=1.01, 95% CIs: 1.00-1.02) and country roadway exposure (HR=1.001. 95% CIs: 1.00-1.02). Conclusions: This study provided evidence that roadway density was positively associated with the risk of hypertension in an Asian population. Wc also found that PM^ served as a mediator for this association.
All Science Journal Classification (ASJC) codes
- Public Health, Environmental and Occupational Health