Robust and brilliant Raman tags based on core-satellite assemblies for brain tumor cell imaging

Yung Ching Chang, Li Ching Huang, Wei Lun Sun, Shih Yi Chuang, Tien Hsin Lin, Yi Syuan Wu, Chun I. Sze, Shiuan Yeh Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

GBM (Glioblastoma Multiforme), a fatal brain tumor, is highly infiltrative and difficult to be completely removed by the surgery. In this work, the Raman tags based on the plasmonic core-satellite assemblies with ∼1 nm internal gap accompanied by extremely high gap field have been fabricated and applied to GBM cell labeling. The brightness of the Raman tags is comparable to the fluorophores. The GBM cells with overexpression of EGFR are labeled with these Raman tags and can be distinguished from the normal cells through Raman imaging.

Original languageEnglish
Title of host publicationBiomedical Vibrational Spectroscopy 2018
Subtitle of host publicationAdvances in Research and Industry
EditorsAnita Mahadevan-Jansen, Wolfgang Petrich
PublisherSPIE
ISBN (Electronic)9781510614659
DOIs
Publication statusPublished - 2018 Jan 1
EventBiomedical Vibrational Spectroscopy 2018: Advances in Research and Industry - San Francisco, United States
Duration: 2018 Jan 272018 Jan 28

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10490
ISSN (Print)1605-7422

Other

OtherBiomedical Vibrational Spectroscopy 2018: Advances in Research and Industry
CountryUnited States
CitySan Francisco
Period18-01-2718-01-28

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All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Chang, Y. C., Huang, L. C., Sun, W. L., Chuang, S. Y., Lin, T. H., Wu, Y. S., Sze, C. I., & Chen, S. Y. (2018). Robust and brilliant Raman tags based on core-satellite assemblies for brain tumor cell imaging. In A. Mahadevan-Jansen, & W. Petrich (Eds.), Biomedical Vibrational Spectroscopy 2018: Advances in Research and Industry [1049006] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10490). SPIE. https://doi.org/10.1117/12.2290194