Robust filtering circuit design for gene networks under intrinsic and extrinsic molecular noises

B. S. Chen, W. S. Wu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

How to design a robust gene network to tolerate intrinsic kinetic parameter variations and to attenuate extrinsic environmental noises to a desired filtering level will be an important topic in metabolic engineering for biotechnological purpose or drug design for therapeutic purpose. At present, there is still no good systematic design method to achieve the robust gene network design. In this study, a gene network suffering from intrinsic kinetic parameter fluctuations and extrinsic environmental noises is modeled as Langevin equation with state-dependent stochastic noises. Based on the nonlinear stochastic filtering theory, a systematic gene circuit design method is proposed to achieve robust stability to tolerate intrinsic noises and to attenuate extrinsic noises to a prescribed filtering level. Computational simulations of a gene network are performed to illustrate the systematic design procedure and to confirm the performance of the proposed robust filtering circuit design in gene networks. The robust gene network design principles have not only yielded a comprehensive design theory of robust gene networks, but also gained valuable insights into the molecular noise filtering of gene networks. The proposed design method could precede the experimental biotechnological method to allow objective numerical improvement strategies for robust gene circuit designs.

Original languageEnglish
Title of host publication2006 IEEE International Conference on Systems, Man and Cybernetics
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages3590-3595
Number of pages6
ISBN (Print)1424401003, 9781424401000
DOIs
Publication statusPublished - 2006 Jan 1
Event2006 IEEE International Conference on Systems, Man and Cybernetics - Taipei, Taiwan
Duration: 2006 Oct 82006 Oct 11

Publication series

NameConference Proceedings - IEEE International Conference on Systems, Man and Cybernetics
Volume5
ISSN (Print)1062-922X

Other

Other2006 IEEE International Conference on Systems, Man and Cybernetics
CountryTaiwan
CityTaipei
Period06-10-0806-10-11

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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  • Cite this

    Chen, B. S., & Wu, W. S. (2006). Robust filtering circuit design for gene networks under intrinsic and extrinsic molecular noises. In 2006 IEEE International Conference on Systems, Man and Cybernetics (pp. 3590-3595). [4274451] (Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics; Vol. 5). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICSMC.2006.384686