Abstract
Urinary beta-2-microglobulin (β2M) and microalbumin concentrations were analyzed in 61 pediatric patients with febrile urinary tract infection (UTI). The results were compared with those of technetium-99m-labeled dimercaptosuccinic acid ( 99m Tc-DMSA) single photon emission computed tomography (SPECT) imaging. Noninvasive evaluations were made to localize the site of the UTI. Increased urinary β2M/Creatinine (Cr) or microalbumin/Cr quotients were not associated with renal inflammation, as defined by a positive renal scan. Increased urinary microalbumin/Cr is associated with UTI in febrile patients regardless of the level of infection (scan status), and may be an informative indicator of UTI. When microalbumin/Cr was ≥0.03, its sensitivity and specificity to predict UTI in febrile patients, regardless of the site of the infection, were 95.65% and 51.79%, respectively, and its positive predictive value was 62.0%. On the other hand, urinary β2M/Cr (≥0.13) demonstrates a statistically significant correlation with the presentation ora high grade of vesicoureteral reflux (p=0.02). We suggest that a prompt renal imaging study is warranted when the urinary β2M/Cr ratio is high (≥0.13).
| Original language | English |
|---|---|
| Pages (from-to) | 84-89 |
| Number of pages | 6 |
| Journal | Acta Paediatrica Taiwanica |
| Volume | 42 |
| Issue number | 2 |
| Publication status | Published - 2001 May 7 |
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All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
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Role of β2-microglobulinuria and microalbuminuria in pediatric febrile urinary tract infection. / Chiou, Yuan-Yow; Chiu, Nan-Tsing; Chen, M. J.; Cheng, Hong-Lin.
In: Acta Paediatrica Taiwanica, Vol. 42, No. 2, 07.05.2001, p. 84-89.Research output: Contribution to journal › Article
TY - JOUR
T1 - Role of β2-microglobulinuria and microalbuminuria in pediatric febrile urinary tract infection
AU - Chiou, Yuan-Yow
AU - Chiu, Nan-Tsing
AU - Chen, M. J.
AU - Cheng, Hong-Lin
PY - 2001/5/7
Y1 - 2001/5/7
N2 - Urinary beta-2-microglobulin (β2M) and microalbumin concentrations were analyzed in 61 pediatric patients with febrile urinary tract infection (UTI). The results were compared with those of technetium-99m-labeled dimercaptosuccinic acid ( 99m Tc-DMSA) single photon emission computed tomography (SPECT) imaging. Noninvasive evaluations were made to localize the site of the UTI. Increased urinary β2M/Creatinine (Cr) or microalbumin/Cr quotients were not associated with renal inflammation, as defined by a positive renal scan. Increased urinary microalbumin/Cr is associated with UTI in febrile patients regardless of the level of infection (scan status), and may be an informative indicator of UTI. When microalbumin/Cr was ≥0.03, its sensitivity and specificity to predict UTI in febrile patients, regardless of the site of the infection, were 95.65% and 51.79%, respectively, and its positive predictive value was 62.0%. On the other hand, urinary β2M/Cr (≥0.13) demonstrates a statistically significant correlation with the presentation ora high grade of vesicoureteral reflux (p=0.02). We suggest that a prompt renal imaging study is warranted when the urinary β2M/Cr ratio is high (≥0.13).
AB - Urinary beta-2-microglobulin (β2M) and microalbumin concentrations were analyzed in 61 pediatric patients with febrile urinary tract infection (UTI). The results were compared with those of technetium-99m-labeled dimercaptosuccinic acid ( 99m Tc-DMSA) single photon emission computed tomography (SPECT) imaging. Noninvasive evaluations were made to localize the site of the UTI. Increased urinary β2M/Creatinine (Cr) or microalbumin/Cr quotients were not associated with renal inflammation, as defined by a positive renal scan. Increased urinary microalbumin/Cr is associated with UTI in febrile patients regardless of the level of infection (scan status), and may be an informative indicator of UTI. When microalbumin/Cr was ≥0.03, its sensitivity and specificity to predict UTI in febrile patients, regardless of the site of the infection, were 95.65% and 51.79%, respectively, and its positive predictive value was 62.0%. On the other hand, urinary β2M/Cr (≥0.13) demonstrates a statistically significant correlation with the presentation ora high grade of vesicoureteral reflux (p=0.02). We suggest that a prompt renal imaging study is warranted when the urinary β2M/Cr ratio is high (≥0.13).
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M3 - Article
VL - 42
SP - 84
EP - 89
JO - Pediatrics and Neonatology
JF - Pediatrics and Neonatology
SN - 1875-9572
IS - 2
ER -