Role of β2-microglobulinuria and microalbuminuria in pediatric febrile urinary tract infection

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Abstract

Urinary beta-2-microglobulin (β2M) and microalbumin concentrations were analyzed in 61 pediatric patients with febrile urinary tract infection (UTI). The results were compared with those of technetium-99m-labeled dimercaptosuccinic acid ( 99m Tc-DMSA) single photon emission computed tomography (SPECT) imaging. Noninvasive evaluations were made to localize the site of the UTI. Increased urinary β2M/Creatinine (Cr) or microalbumin/Cr quotients were not associated with renal inflammation, as defined by a positive renal scan. Increased urinary microalbumin/Cr is associated with UTI in febrile patients regardless of the level of infection (scan status), and may be an informative indicator of UTI. When microalbumin/Cr was ≥0.03, its sensitivity and specificity to predict UTI in febrile patients, regardless of the site of the infection, were 95.65% and 51.79%, respectively, and its positive predictive value was 62.0%. On the other hand, urinary β2M/Cr (≥0.13) demonstrates a statistically significant correlation with the presentation ora high grade of vesicoureteral reflux (p=0.02). We suggest that a prompt renal imaging study is warranted when the urinary β2M/Cr ratio is high (≥0.13).

Original languageEnglish
Pages (from-to)84-89
Number of pages6
JournalActa Paediatrica Taiwanica
Volume42
Issue number2
Publication statusPublished - 2001 May 7

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Urinary Tract Infections
Creatinine
Fever
Pediatrics
Kidney
Technetium Tc 99m Dimercaptosuccinic Acid
Succimer
beta 2-Microglobulin
Vesico-Ureteral Reflux
Infection
Single-Photon Emission-Computed Tomography
Inflammation
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

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title = "Role of β2-microglobulinuria and microalbuminuria in pediatric febrile urinary tract infection",
abstract = "Urinary beta-2-microglobulin (β2M) and microalbumin concentrations were analyzed in 61 pediatric patients with febrile urinary tract infection (UTI). The results were compared with those of technetium-99m-labeled dimercaptosuccinic acid ( 99m Tc-DMSA) single photon emission computed tomography (SPECT) imaging. Noninvasive evaluations were made to localize the site of the UTI. Increased urinary β2M/Creatinine (Cr) or microalbumin/Cr quotients were not associated with renal inflammation, as defined by a positive renal scan. Increased urinary microalbumin/Cr is associated with UTI in febrile patients regardless of the level of infection (scan status), and may be an informative indicator of UTI. When microalbumin/Cr was ≥0.03, its sensitivity and specificity to predict UTI in febrile patients, regardless of the site of the infection, were 95.65{\%} and 51.79{\%}, respectively, and its positive predictive value was 62.0{\%}. On the other hand, urinary β2M/Cr (≥0.13) demonstrates a statistically significant correlation with the presentation ora high grade of vesicoureteral reflux (p=0.02). We suggest that a prompt renal imaging study is warranted when the urinary β2M/Cr ratio is high (≥0.13).",
author = "Yuan-Yow Chiou and Nan-Tsing Chiu and Chen, {M. J.} and Hong-Lin Cheng",
year = "2001",
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T1 - Role of β2-microglobulinuria and microalbuminuria in pediatric febrile urinary tract infection

AU - Chiou, Yuan-Yow

AU - Chiu, Nan-Tsing

AU - Chen, M. J.

AU - Cheng, Hong-Lin

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N2 - Urinary beta-2-microglobulin (β2M) and microalbumin concentrations were analyzed in 61 pediatric patients with febrile urinary tract infection (UTI). The results were compared with those of technetium-99m-labeled dimercaptosuccinic acid ( 99m Tc-DMSA) single photon emission computed tomography (SPECT) imaging. Noninvasive evaluations were made to localize the site of the UTI. Increased urinary β2M/Creatinine (Cr) or microalbumin/Cr quotients were not associated with renal inflammation, as defined by a positive renal scan. Increased urinary microalbumin/Cr is associated with UTI in febrile patients regardless of the level of infection (scan status), and may be an informative indicator of UTI. When microalbumin/Cr was ≥0.03, its sensitivity and specificity to predict UTI in febrile patients, regardless of the site of the infection, were 95.65% and 51.79%, respectively, and its positive predictive value was 62.0%. On the other hand, urinary β2M/Cr (≥0.13) demonstrates a statistically significant correlation with the presentation ora high grade of vesicoureteral reflux (p=0.02). We suggest that a prompt renal imaging study is warranted when the urinary β2M/Cr ratio is high (≥0.13).

AB - Urinary beta-2-microglobulin (β2M) and microalbumin concentrations were analyzed in 61 pediatric patients with febrile urinary tract infection (UTI). The results were compared with those of technetium-99m-labeled dimercaptosuccinic acid ( 99m Tc-DMSA) single photon emission computed tomography (SPECT) imaging. Noninvasive evaluations were made to localize the site of the UTI. Increased urinary β2M/Creatinine (Cr) or microalbumin/Cr quotients were not associated with renal inflammation, as defined by a positive renal scan. Increased urinary microalbumin/Cr is associated with UTI in febrile patients regardless of the level of infection (scan status), and may be an informative indicator of UTI. When microalbumin/Cr was ≥0.03, its sensitivity and specificity to predict UTI in febrile patients, regardless of the site of the infection, were 95.65% and 51.79%, respectively, and its positive predictive value was 62.0%. On the other hand, urinary β2M/Cr (≥0.13) demonstrates a statistically significant correlation with the presentation ora high grade of vesicoureteral reflux (p=0.02). We suggest that a prompt renal imaging study is warranted when the urinary β2M/Cr ratio is high (≥0.13).

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