Role of adiponectin gene variants, adipokines and hydrometry-based percent body fat in metabolically healthy and abnormal obesity

Chin-Sung Chang, Yan Jia Lu, Hsiu Hao Chang, Shih Han Hsu, Po Hsiu Kuo, Chi-Chang Shieh, Wei-Jen Yao, Mei Chi Hsu, Kung-Chia Young, Wen Yuan Lin, Kuo Chin Huang, Chih-Hsing Wu, Yau-Sheng Tsai

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: Metabolically healthy obesity (MHO) subjects have better metabolic parameters than metabolically abnormal obesity (MAO) subjects, but the possible mechanisms underlying this remain unknown. Our study was designed to investigate the interrelationships among genes, adipokines, body fat and its distribution in MHO and MAO. Methods: From 2007 to 2009, 103 males and 131 females aged 18–50 years were enrolled by an intention-to-treat design in a weight management clinic. Participants were divided into MHO and MAO groups. Percent body fat (PBF) was measured by a deuterium oxide dilution method. Four polymorphic variants, including PPARγ2 (Pro12Ala and C1431T) and adiponectin (T45G and G276T) genes, and three adipokines (adiponectin, leptin and resistin) were obtained. Results: Of the 234 obese subjects, 130 (55.6%) were MHO. In the univariate analysis, the MAO group has significantly higher anthropometric, metabolic indices and leptin levels than the MHO group. Logistic regression analysis revealed that age, male gender, the T allele of adiponectin T45G polymorphism, leptin and PBF were positively associated with MAO. ANCOVA analysis revealed that the T allele of adiponectin T45G polymorphism was associated with higher fasting and postprandial glucose levels. We further found that TT genotype has a lower high molecular weight (HMW)/low molecular weight (LMW) adiponectin ratio than GG genotype. Conclusions: The factors associated with MAO are age, male gender, the T allele of adiponectin T45G polymorphism, leptin, and PBF. The net effects of T45G polymorphism on the MAO phenotype may be achieved by changes in the adiponectin oligomer ratio and glucose levels.

Original languageEnglish
Pages (from-to)49-61
Number of pages13
JournalObesity Research and Clinical Practice
Volume12
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Adipokines
Adiponectin
Adipose Tissue
Obesity
Leptin
Genes
Alleles
Molecular Weight
Genotype
Deuterium Oxide
Resistin
Body Fat Distribution
Glucose
Metabolically Benign Obesity
Fasting
Healthy Volunteers
Logistic Models
Regression Analysis
Phenotype
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Chang, Chin-Sung ; Lu, Yan Jia ; Chang, Hsiu Hao ; Hsu, Shih Han ; Kuo, Po Hsiu ; Shieh, Chi-Chang ; Yao, Wei-Jen ; Hsu, Mei Chi ; Young, Kung-Chia ; Lin, Wen Yuan ; Huang, Kuo Chin ; Wu, Chih-Hsing ; Tsai, Yau-Sheng. / Role of adiponectin gene variants, adipokines and hydrometry-based percent body fat in metabolically healthy and abnormal obesity. In: Obesity Research and Clinical Practice. 2018 ; Vol. 12, No. 1. pp. 49-61.
@article{4ae500c535b74db494751e262dd3e0d9,
title = "Role of adiponectin gene variants, adipokines and hydrometry-based percent body fat in metabolically healthy and abnormal obesity",
abstract = "Objective: Metabolically healthy obesity (MHO) subjects have better metabolic parameters than metabolically abnormal obesity (MAO) subjects, but the possible mechanisms underlying this remain unknown. Our study was designed to investigate the interrelationships among genes, adipokines, body fat and its distribution in MHO and MAO. Methods: From 2007 to 2009, 103 males and 131 females aged 18–50 years were enrolled by an intention-to-treat design in a weight management clinic. Participants were divided into MHO and MAO groups. Percent body fat (PBF) was measured by a deuterium oxide dilution method. Four polymorphic variants, including PPARγ2 (Pro12Ala and C1431T) and adiponectin (T45G and G276T) genes, and three adipokines (adiponectin, leptin and resistin) were obtained. Results: Of the 234 obese subjects, 130 (55.6{\%}) were MHO. In the univariate analysis, the MAO group has significantly higher anthropometric, metabolic indices and leptin levels than the MHO group. Logistic regression analysis revealed that age, male gender, the T allele of adiponectin T45G polymorphism, leptin and PBF were positively associated with MAO. ANCOVA analysis revealed that the T allele of adiponectin T45G polymorphism was associated with higher fasting and postprandial glucose levels. We further found that TT genotype has a lower high molecular weight (HMW)/low molecular weight (LMW) adiponectin ratio than GG genotype. Conclusions: The factors associated with MAO are age, male gender, the T allele of adiponectin T45G polymorphism, leptin, and PBF. The net effects of T45G polymorphism on the MAO phenotype may be achieved by changes in the adiponectin oligomer ratio and glucose levels.",
author = "Chin-Sung Chang and Lu, {Yan Jia} and Chang, {Hsiu Hao} and Hsu, {Shih Han} and Kuo, {Po Hsiu} and Chi-Chang Shieh and Wei-Jen Yao and Hsu, {Mei Chi} and Kung-Chia Young and Lin, {Wen Yuan} and Huang, {Kuo Chin} and Chih-Hsing Wu and Yau-Sheng Tsai",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.orcp.2016.05.003",
language = "English",
volume = "12",
pages = "49--61",
journal = "Obesity Research and Clinical Practice",
issn = "1871-403X",
publisher = "Elsevier BV",
number = "1",

}

Role of adiponectin gene variants, adipokines and hydrometry-based percent body fat in metabolically healthy and abnormal obesity. / Chang, Chin-Sung; Lu, Yan Jia; Chang, Hsiu Hao; Hsu, Shih Han; Kuo, Po Hsiu; Shieh, Chi-Chang; Yao, Wei-Jen; Hsu, Mei Chi; Young, Kung-Chia; Lin, Wen Yuan; Huang, Kuo Chin; Wu, Chih-Hsing; Tsai, Yau-Sheng.

In: Obesity Research and Clinical Practice, Vol. 12, No. 1, 01.01.2018, p. 49-61.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Role of adiponectin gene variants, adipokines and hydrometry-based percent body fat in metabolically healthy and abnormal obesity

AU - Chang, Chin-Sung

AU - Lu, Yan Jia

AU - Chang, Hsiu Hao

AU - Hsu, Shih Han

AU - Kuo, Po Hsiu

AU - Shieh, Chi-Chang

AU - Yao, Wei-Jen

AU - Hsu, Mei Chi

AU - Young, Kung-Chia

AU - Lin, Wen Yuan

AU - Huang, Kuo Chin

AU - Wu, Chih-Hsing

AU - Tsai, Yau-Sheng

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objective: Metabolically healthy obesity (MHO) subjects have better metabolic parameters than metabolically abnormal obesity (MAO) subjects, but the possible mechanisms underlying this remain unknown. Our study was designed to investigate the interrelationships among genes, adipokines, body fat and its distribution in MHO and MAO. Methods: From 2007 to 2009, 103 males and 131 females aged 18–50 years were enrolled by an intention-to-treat design in a weight management clinic. Participants were divided into MHO and MAO groups. Percent body fat (PBF) was measured by a deuterium oxide dilution method. Four polymorphic variants, including PPARγ2 (Pro12Ala and C1431T) and adiponectin (T45G and G276T) genes, and three adipokines (adiponectin, leptin and resistin) were obtained. Results: Of the 234 obese subjects, 130 (55.6%) were MHO. In the univariate analysis, the MAO group has significantly higher anthropometric, metabolic indices and leptin levels than the MHO group. Logistic regression analysis revealed that age, male gender, the T allele of adiponectin T45G polymorphism, leptin and PBF were positively associated with MAO. ANCOVA analysis revealed that the T allele of adiponectin T45G polymorphism was associated with higher fasting and postprandial glucose levels. We further found that TT genotype has a lower high molecular weight (HMW)/low molecular weight (LMW) adiponectin ratio than GG genotype. Conclusions: The factors associated with MAO are age, male gender, the T allele of adiponectin T45G polymorphism, leptin, and PBF. The net effects of T45G polymorphism on the MAO phenotype may be achieved by changes in the adiponectin oligomer ratio and glucose levels.

AB - Objective: Metabolically healthy obesity (MHO) subjects have better metabolic parameters than metabolically abnormal obesity (MAO) subjects, but the possible mechanisms underlying this remain unknown. Our study was designed to investigate the interrelationships among genes, adipokines, body fat and its distribution in MHO and MAO. Methods: From 2007 to 2009, 103 males and 131 females aged 18–50 years were enrolled by an intention-to-treat design in a weight management clinic. Participants were divided into MHO and MAO groups. Percent body fat (PBF) was measured by a deuterium oxide dilution method. Four polymorphic variants, including PPARγ2 (Pro12Ala and C1431T) and adiponectin (T45G and G276T) genes, and three adipokines (adiponectin, leptin and resistin) were obtained. Results: Of the 234 obese subjects, 130 (55.6%) were MHO. In the univariate analysis, the MAO group has significantly higher anthropometric, metabolic indices and leptin levels than the MHO group. Logistic regression analysis revealed that age, male gender, the T allele of adiponectin T45G polymorphism, leptin and PBF were positively associated with MAO. ANCOVA analysis revealed that the T allele of adiponectin T45G polymorphism was associated with higher fasting and postprandial glucose levels. We further found that TT genotype has a lower high molecular weight (HMW)/low molecular weight (LMW) adiponectin ratio than GG genotype. Conclusions: The factors associated with MAO are age, male gender, the T allele of adiponectin T45G polymorphism, leptin, and PBF. The net effects of T45G polymorphism on the MAO phenotype may be achieved by changes in the adiponectin oligomer ratio and glucose levels.

UR - http://www.scopus.com/inward/record.url?scp=84969592387&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84969592387&partnerID=8YFLogxK

U2 - 10.1016/j.orcp.2016.05.003

DO - 10.1016/j.orcp.2016.05.003

M3 - Article

VL - 12

SP - 49

EP - 61

JO - Obesity Research and Clinical Practice

JF - Obesity Research and Clinical Practice

SN - 1871-403X

IS - 1

ER -