Role of cognitive parameters in dengue hemorrhagic fever and dengue shock syndrome

Jih Jin Tsai, Kulkanya Chokephaibulkit, Po Chih Chen, Li Teh Liu, Hui Mien Hsiao, Yu Chih Lo, Guey Chuen Perng

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)


Dengue is becoming recognized as one of the most important vector-borne human diseases. It is predominant in tropical and subtropical zones but its geographical distribution is progressively expanding, making it an escalating global health problem of today. Dengue presents with spectrum of clinical manifestations, ranging from asymptomatic, undifferentiated mild fever, dengue fever (DF), to dengue hemorrhagic fever (DHF) with or without shock (DSS), a life-threatening illness characterized by plasma leakage due to increased vascular permeability. Currently, there are no antiviral modalities or vaccines available to treat and prevent dengue. Supportive care with close monitoring is the standard clinical practice. The mechanisms leading to DHF/DSS remains poorly understood. Multiple factors have been attributed to the pathological mechanism, but only a couple of these hypotheses are popular in scientific circles. The current discussion focuses on underappreciated factors, temperature, natural IgM, and endotoxin, which may be critical components playing roles in dengue pathogenesis.

Original languageEnglish
Article number88
JournalJournal of biomedical science
Issue number1
Publication statusPublished - 2013 Dec 5

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)


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