TY - JOUR
T1 - Role of cognitive parameters in dengue hemorrhagic fever and dengue shock syndrome
AU - Tsai, Jih Jin
AU - Chokephaibulkit, Kulkanya
AU - Chen, Po Chih
AU - Liu, Li Teh
AU - Hsiao, Hui Mien
AU - Lo, Yu Chih
AU - Perng, Guey Chuen
N1 - Funding Information:
We would like to thank the clinical staffs at the Tropical Medicine Center and Division of Infectious Diseases of Kaohsiung Medical University Hospital, and at the Division of Infectious Diseases in the Department of Pediatrics at the Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. This study was partially supported by a startup grant from the National Science Council (NSC99-2321-B006-008) (GCP) with the Center of Infectious Disease and Signaling Research, NCKU, Taiwan, National Health Research Institutes (NHRI-EX102-10129SC) and National Science Council (NSC 101-2311-B-006-008-MY3) (YCL), and Grants from Taiwan National Science Council (NSC 99-2745-B-037-002) (JJT).
PY - 2013/12/5
Y1 - 2013/12/5
N2 - Dengue is becoming recognized as one of the most important vector-borne human diseases. It is predominant in tropical and subtropical zones but its geographical distribution is progressively expanding, making it an escalating global health problem of today. Dengue presents with spectrum of clinical manifestations, ranging from asymptomatic, undifferentiated mild fever, dengue fever (DF), to dengue hemorrhagic fever (DHF) with or without shock (DSS), a life-threatening illness characterized by plasma leakage due to increased vascular permeability. Currently, there are no antiviral modalities or vaccines available to treat and prevent dengue. Supportive care with close monitoring is the standard clinical practice. The mechanisms leading to DHF/DSS remains poorly understood. Multiple factors have been attributed to the pathological mechanism, but only a couple of these hypotheses are popular in scientific circles. The current discussion focuses on underappreciated factors, temperature, natural IgM, and endotoxin, which may be critical components playing roles in dengue pathogenesis.
AB - Dengue is becoming recognized as one of the most important vector-borne human diseases. It is predominant in tropical and subtropical zones but its geographical distribution is progressively expanding, making it an escalating global health problem of today. Dengue presents with spectrum of clinical manifestations, ranging from asymptomatic, undifferentiated mild fever, dengue fever (DF), to dengue hemorrhagic fever (DHF) with or without shock (DSS), a life-threatening illness characterized by plasma leakage due to increased vascular permeability. Currently, there are no antiviral modalities or vaccines available to treat and prevent dengue. Supportive care with close monitoring is the standard clinical practice. The mechanisms leading to DHF/DSS remains poorly understood. Multiple factors have been attributed to the pathological mechanism, but only a couple of these hypotheses are popular in scientific circles. The current discussion focuses on underappreciated factors, temperature, natural IgM, and endotoxin, which may be critical components playing roles in dengue pathogenesis.
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U2 - 10.1186/1423-0127-20-88
DO - 10.1186/1423-0127-20-88
M3 - Review article
C2 - 24305068
AN - SCOPUS:84888997780
SN - 1021-7770
VL - 20
JO - Journal of biomedical science
JF - Journal of biomedical science
IS - 1
M1 - 88
ER -