Role of DRD2 and ALDH2 genes in bipolar II disorder with and without comorbid anxiety disorder

Y. S. Wang; S. Y. Lee; S. L. Chen; Y. H. Chang; T. Y. Wang; S. H. Lin; C. L. Wang; S. Y. Huang; I. H. Lee; P. S. Chen; Y. K. Yang; R. B. Lu

doi:10.1016/j.eurpsy.2013.05.001

Role of DRD2 and ALDH2 genes in bipolar II disorder with and without comorbid anxiety disorder

Y. S. Wang, S. Y. Lee, S. L. Chen, Y. H. Chang, T. Y. Wang, S. H. Lin, C. L. Wang, S. Y. Huang, I. H. Lee, P. S. Chen, Y. K. Yang, R. B. Lu

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18 Citations (Scopus)

Abstract

The presence of comorbid anxiety disorders (AD) and bipolar II disorders (BP-II) compounds disability complicates treatment, worsens prognosis, and has been understudied. The genes involved in metabolizing dopamine and encoding dopamine receptors, such as aldehyde dehydrogenase 2 (ALDH2) and dopamine D2 receptor (DRD2) genes, may be important to the pathogenesis of BP-II comorbid with AD. We aimed to clarify ALDH2 and DRD2 genes for predisposition to BP-II comorbid with and without AD. The sample consisted of 335 subjects BP-II without AD, 127 subjects BP-II with AD and 348 healthy subjects as normal control. The genotypes of the ALDH2 and DRD2 Taq-IA polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. Logistic regression analysis showed a statistically significant association between DRD2 Taq-I A1/A2 genotype and BP-II with AD (OR = 2.231, P= 0.021). Moreover, a significant interaction of the DRD2 Taq-I A1/A1 and the ALDH2*1*1 genotypes in BP-II without AD was revealed (OR = 5.623, P= 0.001) compared with normal control. Our findings support the hypothesis that a unique genetic distinction between BP-II with and without AD, and suggest a novel association between DRD2 Taq-I A1/A2 genotype and BP-II with AD. Our study also provides further evidence that the ALDH2 and DRD2 genes interact in BP-II, particularly BP-II without AD.

Original language	English
Pages (from-to)	142-148
Number of pages	7
Journal	European Psychiatry
Volume	29
Issue number	3
DOIs	https://doi.org/10.1016/j.eurpsy.2013.05.001
Publication status	Published - 2014 Mar

All Science Journal Classification (ASJC) codes

Psychiatry and Mental health

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10.1016/j.eurpsy.2013.05.001

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@article{20ccd1664541441092cf4b2421628490,

title = "Role of DRD2 and ALDH2 genes in bipolar II disorder with and without comorbid anxiety disorder",

abstract = "The presence of comorbid anxiety disorders (AD) and bipolar II disorders (BP-II) compounds disability complicates treatment, worsens prognosis, and has been understudied. The genes involved in metabolizing dopamine and encoding dopamine receptors, such as aldehyde dehydrogenase 2 (ALDH2) and dopamine D2 receptor (DRD2) genes, may be important to the pathogenesis of BP-II comorbid with AD. We aimed to clarify ALDH2 and DRD2 genes for predisposition to BP-II comorbid with and without AD. The sample consisted of 335 subjects BP-II without AD, 127 subjects BP-II with AD and 348 healthy subjects as normal control. The genotypes of the ALDH2 and DRD2 Taq-IA polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. Logistic regression analysis showed a statistically significant association between DRD2 Taq-I A1/A2 genotype and BP-II with AD (OR = 2.231, P= 0.021). Moreover, a significant interaction of the DRD2 Taq-I A1/A1 and the ALDH2*1*1 genotypes in BP-II without AD was revealed (OR = 5.623, P= 0.001) compared with normal control. Our findings support the hypothesis that a unique genetic distinction between BP-II with and without AD, and suggest a novel association between DRD2 Taq-I A1/A2 genotype and BP-II with AD. Our study also provides further evidence that the ALDH2 and DRD2 genes interact in BP-II, particularly BP-II without AD.",

author = "Wang, {Y. S.} and Lee, {S. Y.} and Chen, {S. L.} and Chang, {Y. H.} and Wang, {T. Y.} and Lin, {S. H.} and Wang, {C. L.} and Huang, {S. Y.} and Lee, {I. H.} and Chen, {P. S.} and Yang, {Y. K.} and Lu, {R. B.}",

note = "Funding Information: This study was supported in part by the grant DOH95-TD-M-113055 (to Ru-Band Lu) from the Taiwan Ministry of Health ; NHRI-EX97-9738NI , NHRI-EX98-9738NI , NHRI-EX99-9738NI (to Ru-Band Lu) from the National Health Research Institutes ; NSC98-2627-B-006-017 , NSC99-2627-B-006-015 , NSC100-2627-B-006-013 (to Ru-Band Lu), NSC100-2314-B-006-048-MY3 (to Sheng-Yu Lee) from the National Science Council and by the grant from the National Cheng Kung University Project to Promote Academic Excellence & Develop World Class Research Centers (to Ru-Band Lu). We thank Dr. Ying-Ju Wang and Dr. Wen-Heng Zheng for their assistance in correcting English and Mr. Sheng-Chun Yang for her assistance in preparing this manuscript.",

year = "2014",

month = mar,

doi = "10.1016/j.eurpsy.2013.05.001",

language = "English",

volume = "29",

pages = "142--148",

journal = "European Psychiatry",

issn = "0924-9338",

publisher = "Elsevier Masson",

number = "3",

}

TY - JOUR

T1 - Role of DRD2 and ALDH2 genes in bipolar II disorder with and without comorbid anxiety disorder

AU - Wang, Y. S.

AU - Lee, S. Y.

AU - Chen, S. L.

AU - Chang, Y. H.

AU - Wang, T. Y.

AU - Lin, S. H.

AU - Wang, C. L.

AU - Huang, S. Y.

AU - Lee, I. H.

AU - Chen, P. S.

AU - Yang, Y. K.

AU - Lu, R. B.

N1 - Funding Information: This study was supported in part by the grant DOH95-TD-M-113055 (to Ru-Band Lu) from the Taiwan Ministry of Health ; NHRI-EX97-9738NI , NHRI-EX98-9738NI , NHRI-EX99-9738NI (to Ru-Band Lu) from the National Health Research Institutes ; NSC98-2627-B-006-017 , NSC99-2627-B-006-015 , NSC100-2627-B-006-013 (to Ru-Band Lu), NSC100-2314-B-006-048-MY3 (to Sheng-Yu Lee) from the National Science Council and by the grant from the National Cheng Kung University Project to Promote Academic Excellence & Develop World Class Research Centers (to Ru-Band Lu). We thank Dr. Ying-Ju Wang and Dr. Wen-Heng Zheng for their assistance in correcting English and Mr. Sheng-Chun Yang for her assistance in preparing this manuscript.

PY - 2014/3

Y1 - 2014/3

N2 - The presence of comorbid anxiety disorders (AD) and bipolar II disorders (BP-II) compounds disability complicates treatment, worsens prognosis, and has been understudied. The genes involved in metabolizing dopamine and encoding dopamine receptors, such as aldehyde dehydrogenase 2 (ALDH2) and dopamine D2 receptor (DRD2) genes, may be important to the pathogenesis of BP-II comorbid with AD. We aimed to clarify ALDH2 and DRD2 genes for predisposition to BP-II comorbid with and without AD. The sample consisted of 335 subjects BP-II without AD, 127 subjects BP-II with AD and 348 healthy subjects as normal control. The genotypes of the ALDH2 and DRD2 Taq-IA polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. Logistic regression analysis showed a statistically significant association between DRD2 Taq-I A1/A2 genotype and BP-II with AD (OR = 2.231, P= 0.021). Moreover, a significant interaction of the DRD2 Taq-I A1/A1 and the ALDH2*1*1 genotypes in BP-II without AD was revealed (OR = 5.623, P= 0.001) compared with normal control. Our findings support the hypothesis that a unique genetic distinction between BP-II with and without AD, and suggest a novel association between DRD2 Taq-I A1/A2 genotype and BP-II with AD. Our study also provides further evidence that the ALDH2 and DRD2 genes interact in BP-II, particularly BP-II without AD.

AB - The presence of comorbid anxiety disorders (AD) and bipolar II disorders (BP-II) compounds disability complicates treatment, worsens prognosis, and has been understudied. The genes involved in metabolizing dopamine and encoding dopamine receptors, such as aldehyde dehydrogenase 2 (ALDH2) and dopamine D2 receptor (DRD2) genes, may be important to the pathogenesis of BP-II comorbid with AD. We aimed to clarify ALDH2 and DRD2 genes for predisposition to BP-II comorbid with and without AD. The sample consisted of 335 subjects BP-II without AD, 127 subjects BP-II with AD and 348 healthy subjects as normal control. The genotypes of the ALDH2 and DRD2 Taq-IA polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. Logistic regression analysis showed a statistically significant association between DRD2 Taq-I A1/A2 genotype and BP-II with AD (OR = 2.231, P= 0.021). Moreover, a significant interaction of the DRD2 Taq-I A1/A1 and the ALDH2*1*1 genotypes in BP-II without AD was revealed (OR = 5.623, P= 0.001) compared with normal control. Our findings support the hypothesis that a unique genetic distinction between BP-II with and without AD, and suggest a novel association between DRD2 Taq-I A1/A2 genotype and BP-II with AD. Our study also provides further evidence that the ALDH2 and DRD2 genes interact in BP-II, particularly BP-II without AD.

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U2 - 10.1016/j.eurpsy.2013.05.001

DO - 10.1016/j.eurpsy.2013.05.001

M3 - Article

C2 - 23835015

AN - SCOPUS:84896727039

SN - 0924-9338

VL - 29

SP - 142

EP - 148

JO - European Psychiatry

JF - European Psychiatry

IS - 3

ER -

Role of DRD2 and ALDH2 genes in bipolar II disorder with and without comorbid anxiety disorder

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