Roles of macrophage migration inhibitory factor in dengue pathogenesis: From pathogenic factor to therapeutic target

Yen Chung Lai, Chiao Hsuan Chao, Trai Ming Yeh

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Dengue virus (DENV) infection is the most prevalent mosquito-borne viral infection and can lead to severe dengue hemorrhagic fever (DHF) and even life-threatening dengue shock syndrome (DSS). Although the cytokine storm has been revealed as a critical factor in dengue disease, the limited understanding of dengue immunopathogenesis hinders the development of effective treatments. Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine that mediates diverse immune responses, and the serum level of MIF positively correlates with disease severity in patients with dengue. MIF is involved in DENV replication and many pathological changes, such as vascular leakage, during DENV infection. In this paper, the pathogenic roles of MIF and the regulation of MIF secretion during DENV infection are reviewed. Furthermore, whether MIF is a potential therapeutic target against DENV infection is also discussed.

Original languageEnglish
Article number891
Pages (from-to)1-16
Number of pages16
JournalMicroorganisms
Volume8
Issue number6
DOIs
Publication statusPublished - 2020 Jun

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Virology
  • Microbiology (medical)

Fingerprint Dive into the research topics of 'Roles of macrophage migration inhibitory factor in dengue pathogenesis: From pathogenic factor to therapeutic target'. Together they form a unique fingerprint.

Cite this