TY - JOUR
T1 - Roles of macrophage migration inhibitory factor in dengue pathogenesis
T2 - From pathogenic factor to therapeutic target
AU - Lai, Yen Chung
AU - Chao, Chiao Hsuan
AU - Yeh, Trai Ming
N1 - Funding Information:
This study was supported by grants from the Ministry of Science and Technology of Taiwan (107-2321-B-006-001 and 108-2320-B-006-040) and the National Health Research Institute (NHRI-109A1-MRCO-02202013).
Funding Information:
Funding: This study was supported by grants from the Ministry of Science and Technology of Taiwan (107-2321-B-006-001 and 108-2320-B-006 -040) and the National Health Research Institute (NHRI-109A1-MRCO-02202013).
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/6
Y1 - 2020/6
N2 - Dengue virus (DENV) infection is the most prevalent mosquito-borne viral infection and can lead to severe dengue hemorrhagic fever (DHF) and even life-threatening dengue shock syndrome (DSS). Although the cytokine storm has been revealed as a critical factor in dengue disease, the limited understanding of dengue immunopathogenesis hinders the development of effective treatments. Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine that mediates diverse immune responses, and the serum level of MIF positively correlates with disease severity in patients with dengue. MIF is involved in DENV replication and many pathological changes, such as vascular leakage, during DENV infection. In this paper, the pathogenic roles of MIF and the regulation of MIF secretion during DENV infection are reviewed. Furthermore, whether MIF is a potential therapeutic target against DENV infection is also discussed.
AB - Dengue virus (DENV) infection is the most prevalent mosquito-borne viral infection and can lead to severe dengue hemorrhagic fever (DHF) and even life-threatening dengue shock syndrome (DSS). Although the cytokine storm has been revealed as a critical factor in dengue disease, the limited understanding of dengue immunopathogenesis hinders the development of effective treatments. Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine that mediates diverse immune responses, and the serum level of MIF positively correlates with disease severity in patients with dengue. MIF is involved in DENV replication and many pathological changes, such as vascular leakage, during DENV infection. In this paper, the pathogenic roles of MIF and the regulation of MIF secretion during DENV infection are reviewed. Furthermore, whether MIF is a potential therapeutic target against DENV infection is also discussed.
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U2 - 10.3390/microorganisms8060891
DO - 10.3390/microorganisms8060891
M3 - Review article
AN - SCOPUS:85090729670
VL - 8
SP - 1
EP - 16
JO - Microorganisms
JF - Microorganisms
SN - 2076-2607
IS - 6
M1 - 891
ER -