Roles of prostaglandin E2 in endometriosis

Kuei Yang Hsiao, Meng Hsing Wu, Shaw Jenq Tsai

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Endometriosis is one of the most common gynecological diseases, affecting approximately 10 % of women in reproductive age. It is characterized as the presence of endometrial-like glands and stroma outside the uterus, commonly on the pelvic peritoneum and ovaries. The major symptoms of endometriosis include pelvic pain, dysmenorrhea, dyspareunia, and infertility. During the past decade, intensive investigations on molecular mechanisms responsible for the pathological processes of endometriosis have been conducted. Although many factors have been reported to be involved in these processes, prostaglandin E2 (PGE2) no doubt represents as one of the most critical regulators of all. Accumulating data demonstrate that PGE2 controls many critical functions, such as steroidogenesis, angiogenesis, proliferation, and immune suppression that contribute to the pathogenesis of endometriosis. Herein, we will summarize the most up-to-date information regarding the functional roles of PGE2 in the development and maintenance of endometriosis.

Original languageEnglish
Title of host publicationEndometriosis
Subtitle of host publicationPathogenesis and Treatment
PublisherSpringer Japan
Pages125-146
Number of pages22
Volume9784431544210
ISBN (Electronic)9784431544210
ISBN (Print)4431544208, 9784431544203
DOIs
Publication statusPublished - 2014 Jan 1

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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