Salvage therapy with tigecycline for recurrent infection caused by ertapenem-resistant extended-spectrum β-lactamase-producing Klebsiella pneumoniae

Po Lin Chen; Jing Jou Yan; Chi Jung Wu; Hsin Chun Lee; Chia Ming Chang; Nan Yao Lee; Nai Ying Ko; Li Rong Wang; Hsin I. Shih; Ching Chi Lee; Wen Chien Ko

doi:10.1016/j.diagmicrobio.2010.06.009

Salvage therapy with tigecycline for recurrent infection caused by ertapenem-resistant extended-spectrum β-lactamase-producing Klebsiella pneumoniae

Po Lin Chen, Jing Jou Yan, Chi Jung Wu, Hsin Chun Lee, Chia Ming Chang, Nan Yao Lee, Nai Ying Ko, Li Rong Wang, Hsin I. Shih, Ching Chi Lee, Wen Chien Ko

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Optimal antimicrobial therapy for infections due to ertapenem-resistant Enterobacteriaceae remains undetermined. In this study, a diabetic patient with recurrent pyomyositis and osteomyelitis caused by extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae developed ertapenem resistance after imipenem/cilastatin treatment, which was a currently recommended therapy. He was finally treated successfully using tigecycline. Ertapenem resistance was in part explained by the production of SHV-type ESBL and the absence of an outer membrane protein, OmpK36. Our observation suggests that tigecycline may be an alternative for invasive infections caused by ESBL-producing Enterobacteriaceae with decreased susceptibility to carbapenem.

Original language	English
Pages (from-to)	312-314
Number of pages	3
Journal	Diagnostic Microbiology and Infectious Disease
Volume	68
Issue number	3
DOIs	https://doi.org/10.1016/j.diagmicrobio.2010.06.009
Publication status	Published - 2010 Nov

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diagmicrobio.2010.06.009

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Chen, P. L., Yan, J. J., Wu, C. J., Lee, H. C., Chang, C. M., Lee, N. Y., Ko, N. Y., Wang, L. R., Shih, H. I., Lee, C. C., & Ko, W. C. (2010). Salvage therapy with tigecycline for recurrent infection caused by ertapenem-resistant extended-spectrum β-lactamase-producing Klebsiella pneumoniae. Diagnostic Microbiology and Infectious Disease, 68(3), 312-314. https://doi.org/10.1016/j.diagmicrobio.2010.06.009

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title = "Salvage therapy with tigecycline for recurrent infection caused by ertapenem-resistant extended-spectrum β-lactamase-producing Klebsiella pneumoniae",

abstract = "Optimal antimicrobial therapy for infections due to ertapenem-resistant Enterobacteriaceae remains undetermined. In this study, a diabetic patient with recurrent pyomyositis and osteomyelitis caused by extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae developed ertapenem resistance after imipenem/cilastatin treatment, which was a currently recommended therapy. He was finally treated successfully using tigecycline. Ertapenem resistance was in part explained by the production of SHV-type ESBL and the absence of an outer membrane protein, OmpK36. Our observation suggests that tigecycline may be an alternative for invasive infections caused by ESBL-producing Enterobacteriaceae with decreased susceptibility to carbapenem.",

author = "Chen, {Po Lin} and Yan, {Jing Jou} and Wu, {Chi Jung} and Lee, {Hsin Chun} and Chang, {Chia Ming} and Lee, {Nan Yao} and Ko, {Nai Ying} and Wang, {Li Rong} and Shih, {Hsin I.} and Lee, {Ching Chi} and Ko, {Wen Chien}",

year = "2010",

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doi = "10.1016/j.diagmicrobio.2010.06.009",

language = "English",

volume = "68",

pages = "312--314",

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}

Chen, PL, Yan, JJ, Wu, CJ, Lee, HC, Chang, CM , Lee, NY , Ko, NY, Wang, LR, Shih, HI, Lee, CC & Ko, WC 2010, 'Salvage therapy with tigecycline for recurrent infection caused by ertapenem-resistant extended-spectrum β-lactamase-producing Klebsiella pneumoniae', Diagnostic Microbiology and Infectious Disease, vol. 68, no. 3, pp. 312-314. https://doi.org/10.1016/j.diagmicrobio.2010.06.009

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T1 - Salvage therapy with tigecycline for recurrent infection caused by ertapenem-resistant extended-spectrum β-lactamase-producing Klebsiella pneumoniae

AU - Chen, Po Lin

AU - Yan, Jing Jou

AU - Wu, Chi Jung

AU - Lee, Hsin Chun

AU - Chang, Chia Ming

AU - Lee, Nan Yao

AU - Ko, Nai Ying

AU - Wang, Li Rong

AU - Shih, Hsin I.

AU - Lee, Ching Chi

AU - Ko, Wen Chien

PY - 2010/11

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AB - Optimal antimicrobial therapy for infections due to ertapenem-resistant Enterobacteriaceae remains undetermined. In this study, a diabetic patient with recurrent pyomyositis and osteomyelitis caused by extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae developed ertapenem resistance after imipenem/cilastatin treatment, which was a currently recommended therapy. He was finally treated successfully using tigecycline. Ertapenem resistance was in part explained by the production of SHV-type ESBL and the absence of an outer membrane protein, OmpK36. Our observation suggests that tigecycline may be an alternative for invasive infections caused by ESBL-producing Enterobacteriaceae with decreased susceptibility to carbapenem.

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Salvage therapy with tigecycline for recurrent infection caused by ertapenem-resistant extended-spectrum β-lactamase-producing Klebsiella pneumoniae

Abstract

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UN SDGs

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