Salviatalin A and salvitrijudin A, two diterpenes with novel skeletons from roots of Salvia digitaloides and anti-inflammatory evaluation

Shwu Jen Wu; Hsiu Hui Chan; Tsong Long Hwang; Keduo Qian; Susan Morris-Natschke; Kuo Hsiung Lee; Tian Shung Wu

doi:10.1016/j.tetlet.2010.06.048

Salviatalin A and salvitrijudin A, two diterpenes with novel skeletons from roots of Salvia digitaloides and anti-inflammatory evaluation

Shwu Jen Wu, Hsiu Hui Chan, Tsong Long Hwang, Keduo Qian, Susan Morris-Natschke, Kuo Hsiung Lee, Tian Shung Wu

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Salviatalin A (1) and salvitrijudin A (2), two diterpenes with novel skeletons, were isolated from the roots of Salvia digitaloides. Their structures were determined using 1D, 2D NMR, and HRESI-MS spectroscopic analyses. Salviatalin A (1) from bioassay-guided fractionation showed a potent inhibitory effect on superoxide anion production in GMLP/CB-activated human neutrophils as well as other anti-inflammatory effects. A plausible biosynthetic pathway is also discussed.

Original language	English
Pages (from-to)	4287-4290
Number of pages	4
Journal	Tetrahedron Letters
Volume	51
Issue number	32
DOIs	https://doi.org/10.1016/j.tetlet.2010.06.048
Publication status	Published - 2010 Aug 11

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2010.06.048

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title = "Salviatalin A and salvitrijudin A, two diterpenes with novel skeletons from roots of Salvia digitaloides and anti-inflammatory evaluation",

abstract = "Salviatalin A (1) and salvitrijudin A (2), two diterpenes with novel skeletons, were isolated from the roots of Salvia digitaloides. Their structures were determined using 1D, 2D NMR, and HRESI-MS spectroscopic analyses. Salviatalin A (1) from bioassay-guided fractionation showed a potent inhibitory effect on superoxide anion production in GMLP/CB-activated human neutrophils as well as other anti-inflammatory effects. A plausible biosynthetic pathway is also discussed.",

author = "Wu, {Shwu Jen} and Chan, {Hsiu Hui} and Hwang, {Tsong Long} and Keduo Qian and Susan Morris-Natschke and Lee, {Kuo Hsiung} and Wu, {Tian Shung}",

note = "Funding Information: The authors acknowledge the financial support from the National Science Council of Republic of China awarded to T.-S. Wu. This study was supported in part by Taiwan Department of Health Cancer Research Center of Excellence (DOH99-TD-C-111-005). ",

year = "2010",

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doi = "10.1016/j.tetlet.2010.06.048",

language = "English",

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journal = "Tetrahedron Letters",

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AU - Wu, Shwu Jen

AU - Chan, Hsiu Hui

AU - Hwang, Tsong Long

AU - Qian, Keduo

AU - Morris-Natschke, Susan

AU - Lee, Kuo Hsiung

AU - Wu, Tian Shung

N1 - Funding Information: The authors acknowledge the financial support from the National Science Council of Republic of China awarded to T.-S. Wu. This study was supported in part by Taiwan Department of Health Cancer Research Center of Excellence (DOH99-TD-C-111-005).

PY - 2010/8/11

Y1 - 2010/8/11

N2 - Salviatalin A (1) and salvitrijudin A (2), two diterpenes with novel skeletons, were isolated from the roots of Salvia digitaloides. Their structures were determined using 1D, 2D NMR, and HRESI-MS spectroscopic analyses. Salviatalin A (1) from bioassay-guided fractionation showed a potent inhibitory effect on superoxide anion production in GMLP/CB-activated human neutrophils as well as other anti-inflammatory effects. A plausible biosynthetic pathway is also discussed.

AB - Salviatalin A (1) and salvitrijudin A (2), two diterpenes with novel skeletons, were isolated from the roots of Salvia digitaloides. Their structures were determined using 1D, 2D NMR, and HRESI-MS spectroscopic analyses. Salviatalin A (1) from bioassay-guided fractionation showed a potent inhibitory effect on superoxide anion production in GMLP/CB-activated human neutrophils as well as other anti-inflammatory effects. A plausible biosynthetic pathway is also discussed.

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Salviatalin A and salvitrijudin A, two diterpenes with novel skeletons from roots of Salvia digitaloides and anti-inflammatory evaluation

Abstract

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