TY - JOUR
T1 - Saturated saline enhances the effect of electrochemical therapy
AU - Lin, Xi Zhang
AU - Jen, Chung Min
AU - Chou, Chao Kai
AU - Chou, Chao Shan
AU - Sung, Ming Je
AU - Chou, Tse Chuan
N1 - Funding Information:
The study is supported by grants NSC 88-2314-B-006-097-M08 and NSC89-2341-B-006-013-M08 from National Science Council, Executive Yuen, Taiwan.
PY - 2000
Y1 - 2000
N2 - We conducted this experiment to assess the effect of saline injection in electrochemical therapy. Platinum electrodes using direct current were inserted into egg white or liver parenchyma. Pure water or 0.9%, 3%, or 26% sodium chloride were injected into various objects to compare with the control group (no injection). Power was set at 10 V. In the egg-white experiment, gas bubbles and coagulated protein developed around the electrodes. In ex vivo liver, frothy reddish debris developed around the cathodes, while a hardening and shrunken surface occurred around the anodes. The pH was 14 around the cathodes, 0 around the anodes. The electric current, the amount of coagulated protein, and the severity of tissue damage were all in proportion to the concentrations of the injected saline. The volume destroyed in the 26% saline group was 8.1 times larger than that of the control group. Therefore, injected saline, especially saturated saline, can enhance the effect of electrochemical therapy.
AB - We conducted this experiment to assess the effect of saline injection in electrochemical therapy. Platinum electrodes using direct current were inserted into egg white or liver parenchyma. Pure water or 0.9%, 3%, or 26% sodium chloride were injected into various objects to compare with the control group (no injection). Power was set at 10 V. In the egg-white experiment, gas bubbles and coagulated protein developed around the electrodes. In ex vivo liver, frothy reddish debris developed around the cathodes, while a hardening and shrunken surface occurred around the anodes. The pH was 14 around the cathodes, 0 around the anodes. The electric current, the amount of coagulated protein, and the severity of tissue damage were all in proportion to the concentrations of the injected saline. The volume destroyed in the 26% saline group was 8.1 times larger than that of the control group. Therefore, injected saline, especially saturated saline, can enhance the effect of electrochemical therapy.
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U2 - 10.1023/A:1005489022649
DO - 10.1023/A:1005489022649
M3 - Article
C2 - 10749325
AN - SCOPUS:0034080711
SN - 0163-2116
VL - 45
SP - 509
EP - 514
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 3
ER -