Saturation-type transfer function for backpropagation network modeling of biosystems

Mei-Jywan Syu, George T. Tsao

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)


A saturation-type transfer function, bx÷1+|x|, with back-propagation type of neural network (BPN) was proposed for solving problems of several bioreaction systems. The biosystems include multiple components separation, batch cell culture, on-line monitored fermentation system. This saturation-type transfer function was successfully applied to the simulation/prediction, dynamic identification of these practical systems. For the separation of multiple components by adsorption, BPNs with this saturation-type transfer function were applied to the modeling of a series of multicomponent adsorption systems. The results show that the isotherms obtained from the neural network approach well correlate with the experimental data. For batch cell cultures, the initial state strongly governs the growth pattern. A 2-3-8 BPN with initial glucose and cell inoculum as the two inputs, cell densities measured at eight each hours as the eight outputs was constructed. The simulation and prediction results demonstrate again the performance of this transfer function. The ability for extrapolated prediction is also shown. For the on-line monitored fermentation, An inverse-type neural network model of 11-3-1 was designed for the identification of this fermentation. It is modified being able to predict the dynamic response of the 2,3-BDL fermentation. The one-step ahead identification/prediction of this dynamic BPN is thus performed.

Original languageEnglish
Title of host publicationIEEE International Conference on Neural Networks - Conference Proceedings
Number of pages6
Publication statusPublished - 1994
EventProceedings of the 1994 IEEE International Conference on Neural Networks. Part 1 (of 7) - Orlando, FL, USA
Duration: 1994 Jun 271994 Jun 29


OtherProceedings of the 1994 IEEE International Conference on Neural Networks. Part 1 (of 7)
CityOrlando, FL, USA

All Science Journal Classification (ASJC) codes

  • Software


Dive into the research topics of 'Saturation-type transfer function for backpropagation network modeling of biosystems'. Together they form a unique fingerprint.

Cite this