Screening for biliary atresia by infant stool color card in Taiwan

Shan Ming Chen; Mei Hwei Chang; Jung Chieh Du; Chieh Chung Lin; An Chyi Chen; Hung Chang Lee; Beng Huat Lau; Yao Jong Yang; Tzee Chung Wu; Chia Hsiang Chu; Ming Wei Lai; Huey Ling Chen; Shu Fen Wu; Yu Cheng Lin; Lung Huang Lin; Ya Huei Tasi; Wen Terng Lin; Chun Hsien Yu; Shiun Bin Fang; Ching Fing Huang; Hui Wen Chen; Ming Hua Chen; Wn Hsin Wen; Ming Tzong Cheng; Yu Kung Chou; Te Jen Chen

doi:10.1542/peds.2005-1267

Screening for biliary atresia by infant stool color card in Taiwan

Shan Ming Chen, Mei Hwei Chang, Jung Chieh Du, Chieh Chung Lin, An Chyi Chen, Hung Chang Lee, Beng Huat Lau, Yao Jong Yang, Tzee Chung Wu, Chia Hsiang Chu, Ming Wei Lai, Huey Ling Chen, Shu Fen Wu, Yu Cheng Lin, Lung Huang Lin, Ya Huei Tasi, Wen Terng Lin, Chun Hsien Yu, Shiun Bin Fang, Ching Fing HuangHui Wen Chen, Ming Hua Chen, Wn Hsin Wen, Ming Tzong Cheng, Yu Kung Chou, Te Jen Chen

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

141 Citations (Scopus)

Abstract

OBJECTIVE. We aimed to detect biliary atresia (BA) in early infancy to prevent additional liver damage because of the delay of referral and surgical treatment and to investigate the incidence rate of BA in Taiwan. METHODS. A pilot study to screen the stool color in infants for the early diagnosis of BA was undertaken from March 2002 to December 2003. We had designed an "infant stool color card" with 7 numbers of different color pictures and attached it to the child health booklet. Parents were then asked to observe their infant's stool color by using this card. The medical staff would check the number that the parents chose according to their infant's stool color at 1 month of age during the health checkup and then send the card back to the stool color card registry center. RESULTS. The average return rate was ∼65.2% (78 184 infants). A total of 29 infants were diagnosed as having BA, and 26 were screened out by stool color card before 60 days of age. The sensitivity, specificity, and positive predictive value were 89.7%, 99.9%, and 28.6%, respectively. Seventeen (58.6%) infants with BA received a Kasai operation within 60-day age period. The estimated incidence of BA in screened newborns was 3.7 of 10 000. CONCLUSIONS. The stool color card was a simple, efficient, and applicable mass screening method for early diagnosis and management of BA. The program can also help in estimating the incidence and creating a registry of these patients.

Original language	English
Pages (from-to)	1147-1154
Number of pages	8
Journal	Pediatrics
Volume	117
Issue number	4
DOIs	https://doi.org/10.1542/peds.2005-1267
Publication status	Published - 2006

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health

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10.1542/peds.2005-1267

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Chen, S. M., Chang, M. H., Du, J. C., Lin, C. C., Chen, A. C., Lee, H. C., Lau, B. H., Yang, Y. J., Wu, T. C., Chu, C. H., Lai, M. W., Chen, H. L., Wu, S. F., Lin, Y. C., Lin, L. H., Tasi, Y. H., Lin, W. T., Yu, C. H., Fang, S. B., ... Chen, T. J. (2006). Screening for biliary atresia by infant stool color card in Taiwan. Pediatrics, 117(4), 1147-1154. https://doi.org/10.1542/peds.2005-1267

@article{9c75c2ed5acb4f198342eb89a87fc802,

title = "Screening for biliary atresia by infant stool color card in Taiwan",

abstract = "OBJECTIVE. We aimed to detect biliary atresia (BA) in early infancy to prevent additional liver damage because of the delay of referral and surgical treatment and to investigate the incidence rate of BA in Taiwan. METHODS. A pilot study to screen the stool color in infants for the early diagnosis of BA was undertaken from March 2002 to December 2003. We had designed an {"}infant stool color card{"} with 7 numbers of different color pictures and attached it to the child health booklet. Parents were then asked to observe their infant's stool color by using this card. The medical staff would check the number that the parents chose according to their infant's stool color at 1 month of age during the health checkup and then send the card back to the stool color card registry center. RESULTS. The average return rate was ∼65.2% (78 184 infants). A total of 29 infants were diagnosed as having BA, and 26 were screened out by stool color card before 60 days of age. The sensitivity, specificity, and positive predictive value were 89.7%, 99.9%, and 28.6%, respectively. Seventeen (58.6%) infants with BA received a Kasai operation within 60-day age period. The estimated incidence of BA in screened newborns was 3.7 of 10 000. CONCLUSIONS. The stool color card was a simple, efficient, and applicable mass screening method for early diagnosis and management of BA. The program can also help in estimating the incidence and creating a registry of these patients.",

author = "Chen, {Shan Ming} and Chang, {Mei Hwei} and Du, {Jung Chieh} and Lin, {Chieh Chung} and Chen, {An Chyi} and Lee, {Hung Chang} and Lau, {Beng Huat} and Yang, {Yao Jong} and Wu, {Tzee Chung} and Chu, {Chia Hsiang} and Lai, {Ming Wei} and Chen, {Huey Ling} and Wu, {Shu Fen} and Lin, {Yu Cheng} and Lin, {Lung Huang} and Tasi, {Ya Huei} and Lin, {Wen Terng} and Yu, {Chun Hsien} and Fang, {Shiun Bin} and Huang, {Ching Fing} and Chen, {Hui Wen} and Chen, {Ming Hua} and Wen, {Wn Hsin} and Cheng, {Ming Tzong} and Chou, {Yu Kung} and Chen, {Te Jen}",

year = "2006",

doi = "10.1542/peds.2005-1267",

language = "English",

volume = "117",

pages = "1147--1154",

journal = "Pediatrics",

issn = "0031-4005",

publisher = "American Academy of Pediatrics",

number = "4",

}

Chen, SM, Chang, MH, Du, JC, Lin, CC, Chen, AC, Lee, HC, Lau, BH, Yang, YJ, Wu, TC, Chu, CH, Lai, MW, Chen, HL, Wu, SF, Lin, YC, Lin, LH, Tasi, YH, Lin, WT, Yu, CH, Fang, SB, Huang, CF, Chen, HW, Chen, MH, Wen, WH, Cheng, MT, Chou, YK & Chen, TJ 2006, 'Screening for biliary atresia by infant stool color card in Taiwan', Pediatrics, vol. 117, no. 4, pp. 1147-1154. https://doi.org/10.1542/peds.2005-1267

TY - JOUR

T1 - Screening for biliary atresia by infant stool color card in Taiwan

AU - Chen, Shan Ming

AU - Chang, Mei Hwei

AU - Du, Jung Chieh

AU - Lin, Chieh Chung

AU - Chen, An Chyi

AU - Lee, Hung Chang

AU - Lau, Beng Huat

AU - Yang, Yao Jong

AU - Wu, Tzee Chung

AU - Chu, Chia Hsiang

AU - Lai, Ming Wei

AU - Chen, Huey Ling

AU - Wu, Shu Fen

AU - Lin, Yu Cheng

AU - Lin, Lung Huang

AU - Tasi, Ya Huei

AU - Lin, Wen Terng

AU - Yu, Chun Hsien

AU - Fang, Shiun Bin

AU - Huang, Ching Fing

AU - Chen, Hui Wen

AU - Chen, Ming Hua

AU - Wen, Wn Hsin

AU - Cheng, Ming Tzong

AU - Chou, Yu Kung

AU - Chen, Te Jen

PY - 2006

Y1 - 2006

N2 - OBJECTIVE. We aimed to detect biliary atresia (BA) in early infancy to prevent additional liver damage because of the delay of referral and surgical treatment and to investigate the incidence rate of BA in Taiwan. METHODS. A pilot study to screen the stool color in infants for the early diagnosis of BA was undertaken from March 2002 to December 2003. We had designed an "infant stool color card" with 7 numbers of different color pictures and attached it to the child health booklet. Parents were then asked to observe their infant's stool color by using this card. The medical staff would check the number that the parents chose according to their infant's stool color at 1 month of age during the health checkup and then send the card back to the stool color card registry center. RESULTS. The average return rate was ∼65.2% (78 184 infants). A total of 29 infants were diagnosed as having BA, and 26 were screened out by stool color card before 60 days of age. The sensitivity, specificity, and positive predictive value were 89.7%, 99.9%, and 28.6%, respectively. Seventeen (58.6%) infants with BA received a Kasai operation within 60-day age period. The estimated incidence of BA in screened newborns was 3.7 of 10 000. CONCLUSIONS. The stool color card was a simple, efficient, and applicable mass screening method for early diagnosis and management of BA. The program can also help in estimating the incidence and creating a registry of these patients.

AB - OBJECTIVE. We aimed to detect biliary atresia (BA) in early infancy to prevent additional liver damage because of the delay of referral and surgical treatment and to investigate the incidence rate of BA in Taiwan. METHODS. A pilot study to screen the stool color in infants for the early diagnosis of BA was undertaken from March 2002 to December 2003. We had designed an "infant stool color card" with 7 numbers of different color pictures and attached it to the child health booklet. Parents were then asked to observe their infant's stool color by using this card. The medical staff would check the number that the parents chose according to their infant's stool color at 1 month of age during the health checkup and then send the card back to the stool color card registry center. RESULTS. The average return rate was ∼65.2% (78 184 infants). A total of 29 infants were diagnosed as having BA, and 26 were screened out by stool color card before 60 days of age. The sensitivity, specificity, and positive predictive value were 89.7%, 99.9%, and 28.6%, respectively. Seventeen (58.6%) infants with BA received a Kasai operation within 60-day age period. The estimated incidence of BA in screened newborns was 3.7 of 10 000. CONCLUSIONS. The stool color card was a simple, efficient, and applicable mass screening method for early diagnosis and management of BA. The program can also help in estimating the incidence and creating a registry of these patients.

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SN - 0031-4005

VL - 117

SP - 1147

EP - 1154

JO - Pediatrics

JF - Pediatrics

IS - 4

ER -

Screening for biliary atresia by infant stool color card in Taiwan

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