Seborrheic keratosis of conjunctiva simulating a malignant melanoma: An immunocytochemical study with impression cytology

Sung Huei Tseng, Ying Ting Chen, Fu Chin Huang, Ying Tai Jin

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21 Citations (Scopus)


Objective: Seborrheic keratosis on the conjunctiva appears to have never been reported in the literature. The authors report here a well-documented case of seborrheic keratosis of conjunctiva clinically simulating a malignant melanoma. Design: Case report. Methods: A 66-year-old man presented with a juxtalimbal pigmented tumor involving the temporal conjunctiva of his left eye. Because of the rapid enlargement of the mass within a period of 5 months, a clinical diagnosis of malignant melanoma was made. Cytopathologic examinations were performed by impression cytology before the patient underwent a wide en-block excision of the tumor. Main Outcome Measures: Cytologic features were studied by impression cytology with periodic acid- Schiff-Papanicolaou stain. Immunochemical characteristics of tumor cells were studied by immunochemical stain of cytokeratin and HMB-45. Tumor morphology was observed by histopathologic examination. Results: Impression cytology disclosed basaloid cells intermixing with squamoid cells, and these cells demonstrated positive immunoreactivity to cytokeratin and no reactivity to HMB-45. Histopathologic examination of the tumor specimen established the diagnosis of seborrheic keratosis, and the results of immunohistochemical staining were consistent with those of the impression cytology with immunocytochemical staining. Conclusion: The authors describe the first case report of conjunctival seborrheic keratosis and present its immunocytochemical and immunohistochemical characteristics. Such a benign lesion can clinically mimic a malignant melanoma.

Original languageEnglish
Pages (from-to)1516-1520
Number of pages5
Issue number8
Publication statusPublished - 1999 Aug 1

All Science Journal Classification (ASJC) codes

  • Ophthalmology


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