SECONDARY METABOLITES FROM HIGHER FUNGI IN VIET NAM: DISCOVERY, CHEMODIVERSITY, AND BIOACTIVITY

Nguyen Ngoc Tuan, Tran Trung Hieu, Nguyen Thi Ngan, Nguyen Tan Thanh, Hoang Van Trung, Nguyen Thi Bich Ngoc, Ping Chung Kuo, Tian Shung Wu, Tran Dinh Thang

Research output: Contribution to journalReview articlepeer-review

Abstract

Medicinal higher fungi such as Ganoderma, Phellinus and Hexagonia have been used as alternative medicinal remedies to promote health and longevity for people in Viet Nam and other regions of the world since ancient times. Nowadays there is an increasing public interest in the secondary metabolites of Vietnamese higher fungi for discovering new drugs or lead compounds. Current research in drug discovery from medicinal higher fungi involves a multifaceted approach combining mycological, biochemical, pharmacological, metabolic, biosynthetic and molecular techniques. In recent years, many new secondary metabolites from Vietnamese higher fungi have been isolated and are more likely to provide lead compounds for new drug discovery, which may include chemopreventive agents possessing the bioactivity of immunomodulatory, anticancer, etc. However, numerous challenges of secondary metabolites from higher fungi are encountered including separation, identification, biosynthetic metabolism, and screening model, etc. Commercial production of secondary metabolites from medicinal mushrooms is still limited mainly due to less information about secondary metabolism and its regulation. Therefore, strategies for enhancing secondary metabolite production have been continuously developed. At present, Vietnamese higher fungi secondary metabolites can be divided into over 20 major groups according to their chemical types. In this paper, roughly three groups of secondary metabolites derived from higher fungi reported in the past decade are overviewed.

Original languageEnglish
Pages (from-to)1-20
Number of pages20
JournalVietnam Journal of Science and Technology
Volume60
Issue number1
DOIs
Publication statusPublished - 2022 Feb 24

All Science Journal Classification (ASJC) codes

  • Chemistry (miscellaneous)
  • Environmental Science (miscellaneous)

Fingerprint

Dive into the research topics of 'SECONDARY METABOLITES FROM HIGHER FUNGI IN VIET NAM: DISCOVERY, CHEMODIVERSITY, AND BIOACTIVITY'. Together they form a unique fingerprint.

Cite this