Self-organized Mn2+-block copolymer complexes and their use for in vivo MR imaging of biological processes

Nikorn Pothayee, Der-Yow Chen, Maria A. Aronova, Chunqi Qian, Nadia Bouraoud, Stephen Dodd, Richard D. Leapman, Alan P. Koretsky

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Manganese-block copolymer complexes (MnBCs) that contain paramagnetic Mn ions complexed with ionic-nonionic poly(ethylene oxide-b-poly(methacrylate) have been developed for use as a T1-weighted MRI contrast agent. By encasing Mn ions within ionized polymer matrices, r1 values could be increased by 250-350% in comparison with free Mn ions at relatively high fields of 4.7 to 11.7 T. MnBCs were further manipulated by treatment with NaOH to achieve more stable complexes (iMnBCs). iMnBCs delayed release of Mn2+ which could be accelerated by low pH, indeed by cellular uptake via endocytosis into acidic compartments. Both complexes exhibited good T1 contrast signal enhancement in the liver following intravenous infusion. The contrast was observed in the gallbladder due to the clearance of Mn ions from the liver to the biliary process. iMnBCs, notably, showed a delayed contrast enhancement profile in the gallbladder, which was interpreted to be due to degradation and excretion of Mn2+ ions into the gallbladder. Intracortical injection of iMnBCs into the rat brain also led to delayed neuronal transport to the thalamus. The delayed enhancement feature may have benefits for targeting MRI contrast to specific cells and surface receptors that are known to be internalized by endocytosis. This journal is

Original languageEnglish
Pages (from-to)7055-7064
Number of pages10
JournalJournal of Materials Chemistry B
Volume2
Issue number40
DOIs
Publication statusPublished - 2014 Jan 1

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Biological Phenomena
Block copolymers
Ions
Imaging techniques
Gallbladder
Manganese
Endocytosis
Liver
Magnetic resonance imaging
Ethylene Oxide
Methacrylates
Cell Surface Receptors
Polyethylene oxides
Thalamus
Polymer matrix
Intravenous Infusions
Contrast Media
Rats
Brain
Polymers

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Medicine(all)
  • Chemistry(all)
  • Materials Science(all)

Cite this

Pothayee, Nikorn ; Chen, Der-Yow ; Aronova, Maria A. ; Qian, Chunqi ; Bouraoud, Nadia ; Dodd, Stephen ; Leapman, Richard D. ; Koretsky, Alan P. / Self-organized Mn2+-block copolymer complexes and their use for in vivo MR imaging of biological processes. In: Journal of Materials Chemistry B. 2014 ; Vol. 2, No. 40. pp. 7055-7064.
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Pothayee, N, Chen, D-Y, Aronova, MA, Qian, C, Bouraoud, N, Dodd, S, Leapman, RD & Koretsky, AP 2014, 'Self-organized Mn2+-block copolymer complexes and their use for in vivo MR imaging of biological processes', Journal of Materials Chemistry B, vol. 2, no. 40, pp. 7055-7064. https://doi.org/10.1039/c4tb00911h

Self-organized Mn2+-block copolymer complexes and their use for in vivo MR imaging of biological processes. / Pothayee, Nikorn; Chen, Der-Yow; Aronova, Maria A.; Qian, Chunqi; Bouraoud, Nadia; Dodd, Stephen; Leapman, Richard D.; Koretsky, Alan P.

In: Journal of Materials Chemistry B, Vol. 2, No. 40, 01.01.2014, p. 7055-7064.

Research output: Contribution to journalArticle

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T1 - Self-organized Mn2+-block copolymer complexes and their use for in vivo MR imaging of biological processes

AU - Pothayee, Nikorn

AU - Chen, Der-Yow

AU - Aronova, Maria A.

AU - Qian, Chunqi

AU - Bouraoud, Nadia

AU - Dodd, Stephen

AU - Leapman, Richard D.

AU - Koretsky, Alan P.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Manganese-block copolymer complexes (MnBCs) that contain paramagnetic Mn ions complexed with ionic-nonionic poly(ethylene oxide-b-poly(methacrylate) have been developed for use as a T1-weighted MRI contrast agent. By encasing Mn ions within ionized polymer matrices, r1 values could be increased by 250-350% in comparison with free Mn ions at relatively high fields of 4.7 to 11.7 T. MnBCs were further manipulated by treatment with NaOH to achieve more stable complexes (iMnBCs). iMnBCs delayed release of Mn2+ which could be accelerated by low pH, indeed by cellular uptake via endocytosis into acidic compartments. Both complexes exhibited good T1 contrast signal enhancement in the liver following intravenous infusion. The contrast was observed in the gallbladder due to the clearance of Mn ions from the liver to the biliary process. iMnBCs, notably, showed a delayed contrast enhancement profile in the gallbladder, which was interpreted to be due to degradation and excretion of Mn2+ ions into the gallbladder. Intracortical injection of iMnBCs into the rat brain also led to delayed neuronal transport to the thalamus. The delayed enhancement feature may have benefits for targeting MRI contrast to specific cells and surface receptors that are known to be internalized by endocytosis. This journal is

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