SEPT12 deficiency causes sperm nucleus damage and developmental arrest of preimplantation embryos

Ying Hung Lin, Chuan Kai Chou, Yu Ching Hung, I. Shing Yu, Hsien An Pan, Shu Wha Lin, Pao Lin Kuo

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Oocytes fertilized with spermatozoa obtained from Septin 12+/- chimeric mice failed to develop beyond the morula stage after IVF and intracytoplasmic sperm injection because of significant DNA defects in the spermatozoa. Given that SEPT12 is expressed at the edge of the sperm nucleus in both humans and mice, we hypothesized the vital roles of Septin 12 in sperm head shaping, nuclear DNA condensation, and early embryonic development.

Original languageEnglish
Pages (from-to)363-365
Number of pages3
JournalFertility and Sterility
Volume95
Issue number1
DOIs
Publication statusPublished - 2011 Jan

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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