Sequential transplants for respective relapse of hodgkin disease and hemophagocytic lymphohistiocytosis: A treatment dilemma

Yu Hsiang Chang; Pei Jung Lu; Meng Yao Lu; Jyh Seng Wang; Chun Liang Tung; Chen Fu Shaw

doi:10.1097/MPH.0b013e3181b38b4e

Sequential transplants for respective relapse of hodgkin disease and hemophagocytic lymphohistiocytosis: A treatment dilemma

Yu Hsiang Chang, Pei Jung Lu, Meng Yao Lu, Jyh Seng Wang, Chun Liang Tung, Chen Fu Shaw

Institute of Clinical Medicine

Research output: Contribution to journal › Review article › peer-review

12 Citations (Scopus)

Abstract

The association of hemophagocytic lymphohistiocytosis (HLH) with Hodgkin disease (HD) seems to be uncommon. A 9-year-old boy, diagnosed with HD-HLH, received chemotherapy and remained in complete remission for 21 months. Then the patient received the first autologous transplant and unfortunately died due to multiorgan failure after the second allogeneic transplant because of sequentially respective relapse of HD and HLH. The recurrence of HLH with a high Epstein-Barr virus load but without relapse of HD in the patient suggests that Epstein-Barr virus may have a major pathogenetic role in the specific disorder HLH-HD. Detailed reports relating to HLH-HD were also reviewed.

Original language	English
Pages (from-to)	778-781
Number of pages	4
Journal	Journal of Pediatric Hematology/Oncology
Volume	31
Issue number	10
DOIs	https://doi.org/10.1097/MPH.0b013e3181b38b4e
Publication status	Published - 2009 Oct

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1097/MPH.0b013e3181b38b4e

Cite this

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title = "Sequential transplants for respective relapse of hodgkin disease and hemophagocytic lymphohistiocytosis: A treatment dilemma",

abstract = "The association of hemophagocytic lymphohistiocytosis (HLH) with Hodgkin disease (HD) seems to be uncommon. A 9-year-old boy, diagnosed with HD-HLH, received chemotherapy and remained in complete remission for 21 months. Then the patient received the first autologous transplant and unfortunately died due to multiorgan failure after the second allogeneic transplant because of sequentially respective relapse of HD and HLH. The recurrence of HLH with a high Epstein-Barr virus load but without relapse of HD in the patient suggests that Epstein-Barr virus may have a major pathogenetic role in the specific disorder HLH-HD. Detailed reports relating to HLH-HD were also reviewed.",

author = "Chang, {Yu Hsiang} and Lu, {Pei Jung} and Lu, {Meng Yao} and Wang, {Jyh Seng} and Tung, {Chun Liang} and Shaw, {Chen Fu}",

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T2 - A treatment dilemma

AU - Chang, Yu Hsiang

AU - Lu, Pei Jung

AU - Lu, Meng Yao

AU - Wang, Jyh Seng

AU - Tung, Chun Liang

AU - Shaw, Chen Fu

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AB - The association of hemophagocytic lymphohistiocytosis (HLH) with Hodgkin disease (HD) seems to be uncommon. A 9-year-old boy, diagnosed with HD-HLH, received chemotherapy and remained in complete remission for 21 months. Then the patient received the first autologous transplant and unfortunately died due to multiorgan failure after the second allogeneic transplant because of sequentially respective relapse of HD and HLH. The recurrence of HLH with a high Epstein-Barr virus load but without relapse of HD in the patient suggests that Epstein-Barr virus may have a major pathogenetic role in the specific disorder HLH-HD. Detailed reports relating to HLH-HD were also reviewed.

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Sequential transplants for respective relapse of hodgkin disease and hemophagocytic lymphohistiocytosis: A treatment dilemma

Abstract

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