Serotonin 5-HT2C receptors regulate anxiety-like behavior

L. K. Heisler, L. Zhou, P. Bajwa, J. Hsu, L. H. Tecott

Research output: Contribution to journalArticlepeer-review

160 Citations (Scopus)


Central serotonin (5-hydroxytryptamine, 5-HT) systems have been implicated in the pathophysiology and treatment of anxiety disorders, which are among the world's most prevalent psychiatric conditions. Here, we report that the 5-HT2C receptor (5-HT2CR) subtype is critically involved in regulating behaviors characteristic of anxiety using male 5-HT2CR knockout (KO) mice. Specific neural substrates underlying the 5-HT2CR KO anxiolytic phenotype were investigated, and we report that 5-HT 2CR KO mice display a selective blunting of extended amygdala corticotropin-releasing hormone neuronal activation in response to anxiety stimuli. These findings illustrate a mechanism through which 5-HT2CRs affect anxiety-related behavior and provide insight into the neural circuitry mediating the complex psychological process of anxiety.

Original languageEnglish
Pages (from-to)491-496
Number of pages6
JournalGenes, Brain and Behavior
Issue number5
Publication statusPublished - 2007 Jul

All Science Journal Classification (ASJC) codes

  • Genetics
  • Neurology
  • Behavioral Neuroscience

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