TY - JOUR
T1 - Serotonin transporter availability may moderate the association between perceiving stress and depressive tendencies - A SPECT with 5-HTTLPR genotyping study
AU - Lin, Shih Hsien
AU - Lee, I. Hui
AU - Chen, Kao Chin
AU - Chen, Po See
AU - Chiu, Nan Tsing
AU - Yao, Wei Jen
AU - Yang, Yen Kuang
N1 - Funding Information:
This study was financially supported by the National Science Council of Taiwan ( NSC 93-2314-B-006-107 , NSC 95-2314-B-006-115-MY2 , NSC 97-2314-B-006-006-MY3 , NSC 101-2314-B-006-065 ), the Atomic Energy Council of Taiwan ( NSC93-NU-7-006-004 , INER 962014L , INER 970930L , INER NL81376 , NSC 99-NU-E-006-003 ), and National Cheng Kung University Hospital NCKUH-9903019 ). This research also received funding ( D102-35001 and D103-35A09 ) from the Headquarters of University Advancement at the National Cheng Kung University, which is sponsored by the Ministry of Education, Taiwan, ROC . The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors declare that they have no conflicts of interest in relation to this work.
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/8/3
Y1 - 2015/8/3
N2 - It was found that serotonin transporter (SERT) gene (5-HTTLPR) polymorphism may moderate the association between perceiving stress and depressive tendency. Although SERT availability in the central nervous system could be associated with 5-HTTLPR polymorphism, whether SERT availability moderates the association between stress and depressive tendency is unclear. This study aimed to investigate whether there is a SERT availability×environmental stress interaction effect, as well as a gene-by-environmental (G×E) interaction effect, using single-photon emission computed tomography (SPECT) with a serotonin transporter radiotracer, [123I]ADAM. 87 healthy volunteers were enrolled. The SERT availability was approximated using SPECT with [123I]ADAM. Stress and depressive tendencies were measured by the Recent Life Change Questionnaire (RLCQ) and the Taiwanese Depression Questionnaire (TDQ), respectively. A significant interaction of sex×RLCQ×thalamic SERT availability on the TDQ was found, and this effect was robust after controlling for the effect of the SS genotype. The interaction of RLCQ×thalamic SERT availability on the TDQ was significant among males. In particular, a significant association between RLCQ and TDQ (Spearman correlation, ρ=0.64, p<0.01) was found among male subjects with a lower level of thalamic SERT availability. SERT availability may play a role in depressive tendency when under perceived stress among healthy individuals, independent of G×E. This finding provides new evidence that confirms the role of the serotonergic system in the association between stress and depression. Males with lower levels of SERT availability may be more vulnerable to the effects of negative life events.
AB - It was found that serotonin transporter (SERT) gene (5-HTTLPR) polymorphism may moderate the association between perceiving stress and depressive tendency. Although SERT availability in the central nervous system could be associated with 5-HTTLPR polymorphism, whether SERT availability moderates the association between stress and depressive tendency is unclear. This study aimed to investigate whether there is a SERT availability×environmental stress interaction effect, as well as a gene-by-environmental (G×E) interaction effect, using single-photon emission computed tomography (SPECT) with a serotonin transporter radiotracer, [123I]ADAM. 87 healthy volunteers were enrolled. The SERT availability was approximated using SPECT with [123I]ADAM. Stress and depressive tendencies were measured by the Recent Life Change Questionnaire (RLCQ) and the Taiwanese Depression Questionnaire (TDQ), respectively. A significant interaction of sex×RLCQ×thalamic SERT availability on the TDQ was found, and this effect was robust after controlling for the effect of the SS genotype. The interaction of RLCQ×thalamic SERT availability on the TDQ was significant among males. In particular, a significant association between RLCQ and TDQ (Spearman correlation, ρ=0.64, p<0.01) was found among male subjects with a lower level of thalamic SERT availability. SERT availability may play a role in depressive tendency when under perceived stress among healthy individuals, independent of G×E. This finding provides new evidence that confirms the role of the serotonergic system in the association between stress and depression. Males with lower levels of SERT availability may be more vulnerable to the effects of negative life events.
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U2 - 10.1016/j.pnpbp.2015.03.009
DO - 10.1016/j.pnpbp.2015.03.009
M3 - Article
C2 - 25816791
AN - SCOPUS:84961335878
SN - 0278-5846
VL - 61
SP - 24
EP - 29
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
ER -