Serotyping and antimicrobial susceptibility of group B streptococcus over an eight-year period in southern Taiwan

Wen-Chien Ko, H. C. Lee, L. R. Wang, C. T. Lee, A. J. Liu, J. J. Wu

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Abstract

The increase in penicillin resistance among pneumococci and viridans streptococci and the development of serotype-specific conjugate vaccine have increased the need for knowledge of the antimicrobial susceptibility and the capsular serotypes of group B streptococci. Over an 8-year period, 351 group B streptococcal isolates from southern Taiwan were tested for antimicrobial susceptibility and serotype determination. Eighty-seven percent of the isolates were typeable. Types III (28.5%) and V (27.1%) were the most common serotypes. The occurrence of type V isolates increased with age, while that of type III isolates decreased with age, showing a predominance in children less than 1 year of age. Of 118 isolates from cases of invasive infection, types Ia, Ib, II, III, IV, and V accounted for 12.7, 11.9, 0.8, 33, 1.7, and 26.3%, respectively. Using the agar dilution method, all isolates were found to be susceptible to penicillin, cefotaxime, and vancomycin, 99.4% to ofloxacin, 78.1% to chloramphenicol, 63.2% to azithromycin, 62.6% to erythromycin, 57.3% to clindamycin, and 2.8% to tetracycline. Chloramphenicol resistance was associated with type III isolates (59 of 100, 59%) and erythromycin and azithromycin resistance with type Ib isolates (25 of 33 [76%], and 21 of 33 [64%], respectively). Thus, 72% of the isolates from invasive infections were serotype III, V, or Ia, and penicillin remains the drug of choice for treatment or prophylaxis of group B streptococcal infections in southern Taiwan, despite the high prevalence of penicillin resistance among Streptococcus pneumoniae and viridans streptococci.

Original languageEnglish
Pages (from-to)334-339
Number of pages6
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume20
Issue number5
Publication statusPublished - 2001 Nov 12

Fingerprint

Serotyping
Streptococcus agalactiae
Taiwan
Viridans Streptococci
Penicillin Resistance
Azithromycin
Erythromycin
Streptococcus pneumoniae
Penicillins
Chloramphenicol Resistance
Streptococcal Infections
Conjugate Vaccines
Ofloxacin
Cefotaxime
Clindamycin
Chloramphenicol
Vancomycin
Infection
Tetracycline
Agar

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Immunology

Cite this

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title = "Serotyping and antimicrobial susceptibility of group B streptococcus over an eight-year period in southern Taiwan",
abstract = "The increase in penicillin resistance among pneumococci and viridans streptococci and the development of serotype-specific conjugate vaccine have increased the need for knowledge of the antimicrobial susceptibility and the capsular serotypes of group B streptococci. Over an 8-year period, 351 group B streptococcal isolates from southern Taiwan were tested for antimicrobial susceptibility and serotype determination. Eighty-seven percent of the isolates were typeable. Types III (28.5{\%}) and V (27.1{\%}) were the most common serotypes. The occurrence of type V isolates increased with age, while that of type III isolates decreased with age, showing a predominance in children less than 1 year of age. Of 118 isolates from cases of invasive infection, types Ia, Ib, II, III, IV, and V accounted for 12.7, 11.9, 0.8, 33, 1.7, and 26.3{\%}, respectively. Using the agar dilution method, all isolates were found to be susceptible to penicillin, cefotaxime, and vancomycin, 99.4{\%} to ofloxacin, 78.1{\%} to chloramphenicol, 63.2{\%} to azithromycin, 62.6{\%} to erythromycin, 57.3{\%} to clindamycin, and 2.8{\%} to tetracycline. Chloramphenicol resistance was associated with type III isolates (59 of 100, 59{\%}) and erythromycin and azithromycin resistance with type Ib isolates (25 of 33 [76{\%}], and 21 of 33 [64{\%}], respectively). Thus, 72{\%} of the isolates from invasive infections were serotype III, V, or Ia, and penicillin remains the drug of choice for treatment or prophylaxis of group B streptococcal infections in southern Taiwan, despite the high prevalence of penicillin resistance among Streptococcus pneumoniae and viridans streptococci.",
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Serotyping and antimicrobial susceptibility of group B streptococcus over an eight-year period in southern Taiwan. / Ko, Wen-Chien; Lee, H. C.; Wang, L. R.; Lee, C. T.; Liu, A. J.; Wu, J. J.

In: European Journal of Clinical Microbiology and Infectious Diseases, Vol. 20, No. 5, 12.11.2001, p. 334-339.

Research output: Contribution to journalArticle

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AB - The increase in penicillin resistance among pneumococci and viridans streptococci and the development of serotype-specific conjugate vaccine have increased the need for knowledge of the antimicrobial susceptibility and the capsular serotypes of group B streptococci. Over an 8-year period, 351 group B streptococcal isolates from southern Taiwan were tested for antimicrobial susceptibility and serotype determination. Eighty-seven percent of the isolates were typeable. Types III (28.5%) and V (27.1%) were the most common serotypes. The occurrence of type V isolates increased with age, while that of type III isolates decreased with age, showing a predominance in children less than 1 year of age. Of 118 isolates from cases of invasive infection, types Ia, Ib, II, III, IV, and V accounted for 12.7, 11.9, 0.8, 33, 1.7, and 26.3%, respectively. Using the agar dilution method, all isolates were found to be susceptible to penicillin, cefotaxime, and vancomycin, 99.4% to ofloxacin, 78.1% to chloramphenicol, 63.2% to azithromycin, 62.6% to erythromycin, 57.3% to clindamycin, and 2.8% to tetracycline. Chloramphenicol resistance was associated with type III isolates (59 of 100, 59%) and erythromycin and azithromycin resistance with type Ib isolates (25 of 33 [76%], and 21 of 33 [64%], respectively). Thus, 72% of the isolates from invasive infections were serotype III, V, or Ia, and penicillin remains the drug of choice for treatment or prophylaxis of group B streptococcal infections in southern Taiwan, despite the high prevalence of penicillin resistance among Streptococcus pneumoniae and viridans streptococci.

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