Sesame lignan sesamol protects against aspirin-induced gastric mucosal damage in rats

Dur Zong Hsu, Pei Yi Chu, Victor Raj Mohan Chandrasekaran, Ming Yie Liu

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Non-steroidal anti-inflammatory drugs are commonly used to control pain, fever, and various inflammatory diseases; however, they have been identified as gastro-toxic. The aim of the present study was to evaluate the effect of aspirin plus sesamol on gastric mucosa in rats. Rats were given oral aspirin (30 mg/kg/d) and oral sesamol (ranging from 0 to 30 mg/kg/day) for 5 weeks, after which their gastric mucosal integrity, oxidative stress, inflammation, and neutrophil infiltration were assessed 6 h after gastric surgery. Sesamol dose-dependently decreased aspirin-induced gastric haemorrhage and mucosal ulceration, and significantly reduced (a) gastric mucosal lipid peroxidation, (b) nitric oxide production, (c) gastric mucosal proinflammatory cytokines (tumor necrosis factor-α and interleukin 1-β levels), and (d) the activity of gastric mucosal myeloperoxidase compared with aspirin-alone groups. We hypothesize that aspirin plus sesamol decreases aspirin-induced gastro-toxicity by inhibiting neutrophil infiltration and subsequent gastric mucosal inflammation and oxidative stress in rats.

Original languageEnglish
Pages (from-to)349-355
Number of pages7
JournalJournal of Functional Foods
Volume1
Issue number4
DOIs
Publication statusPublished - 2009 Oct 1

Fingerprint

Sesamum
Lignans
aspirin
lignans
Aspirin
Stomach
stomach
rats
Neutrophil Infiltration
neutrophils
mouth
Oxidative Stress
oxidative stress
inflammation
Inflammation
myeloperoxidase
gastric mucosa
tumor necrosis factors
Poisons
nonsteroidal anti-inflammatory agents

All Science Journal Classification (ASJC) codes

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Hsu, Dur Zong ; Chu, Pei Yi ; Chandrasekaran, Victor Raj Mohan ; Liu, Ming Yie. / Sesame lignan sesamol protects against aspirin-induced gastric mucosal damage in rats. In: Journal of Functional Foods. 2009 ; Vol. 1, No. 4. pp. 349-355.
@article{48016908f7c044baa118f36b98fbfd73,
title = "Sesame lignan sesamol protects against aspirin-induced gastric mucosal damage in rats",
abstract = "Non-steroidal anti-inflammatory drugs are commonly used to control pain, fever, and various inflammatory diseases; however, they have been identified as gastro-toxic. The aim of the present study was to evaluate the effect of aspirin plus sesamol on gastric mucosa in rats. Rats were given oral aspirin (30 mg/kg/d) and oral sesamol (ranging from 0 to 30 mg/kg/day) for 5 weeks, after which their gastric mucosal integrity, oxidative stress, inflammation, and neutrophil infiltration were assessed 6 h after gastric surgery. Sesamol dose-dependently decreased aspirin-induced gastric haemorrhage and mucosal ulceration, and significantly reduced (a) gastric mucosal lipid peroxidation, (b) nitric oxide production, (c) gastric mucosal proinflammatory cytokines (tumor necrosis factor-α and interleukin 1-β levels), and (d) the activity of gastric mucosal myeloperoxidase compared with aspirin-alone groups. We hypothesize that aspirin plus sesamol decreases aspirin-induced gastro-toxicity by inhibiting neutrophil infiltration and subsequent gastric mucosal inflammation and oxidative stress in rats.",
author = "Hsu, {Dur Zong} and Chu, {Pei Yi} and Chandrasekaran, {Victor Raj Mohan} and Liu, {Ming Yie}",
year = "2009",
month = "10",
day = "1",
doi = "10.1016/j.jff.2009.07.003",
language = "English",
volume = "1",
pages = "349--355",
journal = "Journal of Functional Foods",
issn = "1756-4646",
publisher = "Elsevier Limited",
number = "4",

}

Sesame lignan sesamol protects against aspirin-induced gastric mucosal damage in rats. / Hsu, Dur Zong; Chu, Pei Yi; Chandrasekaran, Victor Raj Mohan; Liu, Ming Yie.

In: Journal of Functional Foods, Vol. 1, No. 4, 01.10.2009, p. 349-355.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sesame lignan sesamol protects against aspirin-induced gastric mucosal damage in rats

AU - Hsu, Dur Zong

AU - Chu, Pei Yi

AU - Chandrasekaran, Victor Raj Mohan

AU - Liu, Ming Yie

PY - 2009/10/1

Y1 - 2009/10/1

N2 - Non-steroidal anti-inflammatory drugs are commonly used to control pain, fever, and various inflammatory diseases; however, they have been identified as gastro-toxic. The aim of the present study was to evaluate the effect of aspirin plus sesamol on gastric mucosa in rats. Rats were given oral aspirin (30 mg/kg/d) and oral sesamol (ranging from 0 to 30 mg/kg/day) for 5 weeks, after which their gastric mucosal integrity, oxidative stress, inflammation, and neutrophil infiltration were assessed 6 h after gastric surgery. Sesamol dose-dependently decreased aspirin-induced gastric haemorrhage and mucosal ulceration, and significantly reduced (a) gastric mucosal lipid peroxidation, (b) nitric oxide production, (c) gastric mucosal proinflammatory cytokines (tumor necrosis factor-α and interleukin 1-β levels), and (d) the activity of gastric mucosal myeloperoxidase compared with aspirin-alone groups. We hypothesize that aspirin plus sesamol decreases aspirin-induced gastro-toxicity by inhibiting neutrophil infiltration and subsequent gastric mucosal inflammation and oxidative stress in rats.

AB - Non-steroidal anti-inflammatory drugs are commonly used to control pain, fever, and various inflammatory diseases; however, they have been identified as gastro-toxic. The aim of the present study was to evaluate the effect of aspirin plus sesamol on gastric mucosa in rats. Rats were given oral aspirin (30 mg/kg/d) and oral sesamol (ranging from 0 to 30 mg/kg/day) for 5 weeks, after which their gastric mucosal integrity, oxidative stress, inflammation, and neutrophil infiltration were assessed 6 h after gastric surgery. Sesamol dose-dependently decreased aspirin-induced gastric haemorrhage and mucosal ulceration, and significantly reduced (a) gastric mucosal lipid peroxidation, (b) nitric oxide production, (c) gastric mucosal proinflammatory cytokines (tumor necrosis factor-α and interleukin 1-β levels), and (d) the activity of gastric mucosal myeloperoxidase compared with aspirin-alone groups. We hypothesize that aspirin plus sesamol decreases aspirin-induced gastro-toxicity by inhibiting neutrophil infiltration and subsequent gastric mucosal inflammation and oxidative stress in rats.

UR - http://www.scopus.com/inward/record.url?scp=70449720552&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70449720552&partnerID=8YFLogxK

U2 - 10.1016/j.jff.2009.07.003

DO - 10.1016/j.jff.2009.07.003

M3 - Article

AN - SCOPUS:70449720552

VL - 1

SP - 349

EP - 355

JO - Journal of Functional Foods

JF - Journal of Functional Foods

SN - 1756-4646

IS - 4

ER -