Sesame oil attenuates acute iron-induced lipid peroxidation-associated hepatic damage in mice

Dur Zong Hsu, Ke Ting Chen, Se Ping Chien, Ya Hui Li, Bu-Miin Huang, Yin Ching Chuang, Ming-Yi Liu

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Acute iron intoxication from the accidental ingestion of iron-containing preparations is one important cause of death in children. The aim of this study was to investigate the protective effect of sesame oil on acute iron-induced lipid peroxidation (LPO) and hepatic injury in mice. Acute iron intoxication was induced by giving ferric nitrilotriacetate to mice. Hepatic function was assessed using blood biochemistry. Free radicals were determined using a high-performance chemiluminescence analyzer. Ferric nitrilotriacetate increased serum ferrous (Fe) and LPO levels, and induced acute hepatic injury. Sesame oil (a) dose-dependently decreased acute iron-induced LPO and hepatic injury, (b) reduced acute iron-associated hydroxyl radical and superoxide anion generation, and (c) inhibited the activity of xanthine oxidase in acute iron in toxication. Thus, sesame oil might ameliorate LPO and acute hepatic injury by inhibiting xanthine oxidase-initiated superoxide anion generation, thereby reducing hydroxyl radical production, at least partially, in acutely iron-intoxicated mice.

Original languageEnglish
Pages (from-to)625-630
Number of pages6
JournalShock
Volume26
Issue number6
DOIs
Publication statusPublished - 2006 Dec 1

All Science Journal Classification (ASJC) codes

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

Fingerprint Dive into the research topics of 'Sesame oil attenuates acute iron-induced lipid peroxidation-associated hepatic damage in mice'. Together they form a unique fingerprint.

Cite this