TY - JOUR
T1 - Sesame oil attenuates multiple organ failure and increases survival rate during endotoxemia in rats
AU - Hsu, Dur Zong
AU - Liu, Ming Yie
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Objective: To investigate the effects and the possible mechanism of sesame oil on multiple organ failure induced by lipopolysaccharide in rats. Design: Laboratory in vivo study of the effects of sesame oil on serum aspartate aminotransferase, γ-glutamyltransferase, alkaline phosphatase, total bilirubin, blood urea nitrogen, creatinine, lipid peroxide, and nitric oxide concentrations. To assess the effect of sesame oil on xanthine oxidase, serum uric acid was measured. Furthermore, lipid peroxide concentrations in liver and kidney were determined. Setting: University laboratory. Subjects: Male Wistar rats. interventions: Blood testing. Measurement and Main Results: Serum aspartate aminotransferase, γ-glutamyltransferase, alkaline phosphatase, total bilirubin, blood urea nitrogen, creatinine, and uric acid concentrations were determined. Lipid peroxide was analyzed by using a commercial kit. Nitric oxide production was estimated by Griess reaction. Sesame oil ameliorated hepatic and renal damage in a dose-dependent manner and increased animal survival in lipopolysaccharide-treated rats. Sesame oil decreased lipid peroxide concentration in serum but not in liver and kidney. Serum nitrite production was unaffected by sesame oil ingestion. Furthermore, the activity of xanthine oxidase was reduced by sesame oil in lipopolysaccharide-challenged rats. Conclusion: Sesame oil ameliorated multiple organ failure and mortality via its inhibition of xanthine oxidase in lipopolysaccharide-dosed rats. Xanthine oxidase may play a critical role in sesame oil-associated organ protection during endotoxemia in rats.
AB - Objective: To investigate the effects and the possible mechanism of sesame oil on multiple organ failure induced by lipopolysaccharide in rats. Design: Laboratory in vivo study of the effects of sesame oil on serum aspartate aminotransferase, γ-glutamyltransferase, alkaline phosphatase, total bilirubin, blood urea nitrogen, creatinine, lipid peroxide, and nitric oxide concentrations. To assess the effect of sesame oil on xanthine oxidase, serum uric acid was measured. Furthermore, lipid peroxide concentrations in liver and kidney were determined. Setting: University laboratory. Subjects: Male Wistar rats. interventions: Blood testing. Measurement and Main Results: Serum aspartate aminotransferase, γ-glutamyltransferase, alkaline phosphatase, total bilirubin, blood urea nitrogen, creatinine, and uric acid concentrations were determined. Lipid peroxide was analyzed by using a commercial kit. Nitric oxide production was estimated by Griess reaction. Sesame oil ameliorated hepatic and renal damage in a dose-dependent manner and increased animal survival in lipopolysaccharide-treated rats. Sesame oil decreased lipid peroxide concentration in serum but not in liver and kidney. Serum nitrite production was unaffected by sesame oil ingestion. Furthermore, the activity of xanthine oxidase was reduced by sesame oil in lipopolysaccharide-challenged rats. Conclusion: Sesame oil ameliorated multiple organ failure and mortality via its inhibition of xanthine oxidase in lipopolysaccharide-dosed rats. Xanthine oxidase may play a critical role in sesame oil-associated organ protection during endotoxemia in rats.
UR - http://www.scopus.com/inward/record.url?scp=0036345714&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036345714&partnerID=8YFLogxK
U2 - 10.1097/00003246-200208000-00031
DO - 10.1097/00003246-200208000-00031
M3 - Article
C2 - 12163806
AN - SCOPUS:0036345714
SN - 0090-3493
VL - 30
SP - 1859
EP - 1862
JO - Critical care medicine
JF - Critical care medicine
IS - 8
ER -