Sesame oil attenuates multiple organ failure and increases survival rate during endotoxemia in rats

Dur Zong Hsu, Ming Yie Liu

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

Objective: To investigate the effects and the possible mechanism of sesame oil on multiple organ failure induced by lipopolysaccharide in rats. Design: Laboratory in vivo study of the effects of sesame oil on serum aspartate aminotransferase, γ-glutamyltransferase, alkaline phosphatase, total bilirubin, blood urea nitrogen, creatinine, lipid peroxide, and nitric oxide concentrations. To assess the effect of sesame oil on xanthine oxidase, serum uric acid was measured. Furthermore, lipid peroxide concentrations in liver and kidney were determined. Setting: University laboratory. Subjects: Male Wistar rats. interventions: Blood testing. Measurement and Main Results: Serum aspartate aminotransferase, γ-glutamyltransferase, alkaline phosphatase, total bilirubin, blood urea nitrogen, creatinine, and uric acid concentrations were determined. Lipid peroxide was analyzed by using a commercial kit. Nitric oxide production was estimated by Griess reaction. Sesame oil ameliorated hepatic and renal damage in a dose-dependent manner and increased animal survival in lipopolysaccharide-treated rats. Sesame oil decreased lipid peroxide concentration in serum but not in liver and kidney. Serum nitrite production was unaffected by sesame oil ingestion. Furthermore, the activity of xanthine oxidase was reduced by sesame oil in lipopolysaccharide-challenged rats. Conclusion: Sesame oil ameliorated multiple organ failure and mortality via its inhibition of xanthine oxidase in lipopolysaccharide-dosed rats. Xanthine oxidase may play a critical role in sesame oil-associated organ protection during endotoxemia in rats.

Original languageEnglish
Pages (from-to)1859-1862
Number of pages4
JournalCritical care medicine
Volume30
Issue number8
DOIs
Publication statusPublished - 2002 Jan 1

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine

Fingerprint

Dive into the research topics of 'Sesame oil attenuates multiple organ failure and increases survival rate during endotoxemia in rats'. Together they form a unique fingerprint.

Cite this