Sesame oil protects against lead-plus-lipopolysaccharide-induced acute hepatic injury

Dur Zong Hsu, Ke Ting Chen, Pei Yi Chu, Ya Hui Li, Ming-Yi Liu

Research output: Contribution to journalArticle

17 Citations (Scopus)


Lead (Pb) increases lipopolysaccharide (LPS)-induced tumor necrosis factor α, which causes liver damage. In this study, we investigated the effect of sesame oil on Pb-plus-LPS (Pb + LPS)-induced acute liver damage in mice. Mice were given sesame oil (8 mL/kg orally) just after Pb acetate (10 mmol/kg i.p.) plus LPS (5 mg/kg i.p.). Aspartate aminotransferase, alanine aminotransferase, tumor necrosis factor-α, interleukin-1β, nitric oxide, and inducible nitric oxide synthase levels were examined. Sesame oil significantly decreased serum aspartate aminotransferase and alanine aminotransferase levels in Pb + LPS-stimulated mice. Sesame oil reduced Pb + LPS-induced tumor necrosis factor-α, interleukin-1β, and nitric oxide production in serum and liver tissue. Furthermore, sesame oil decreased inducible nitric oxide synthase expression in leukocytes and liver tissue in Pb + LPS-treated mice. We hypothesize that the inhibition of proinflammatory cytokines and nitric oxide might be involved in sesame oil-associated protection against Pb + LPS-induced acute hepatic injury in mice.

Original languageEnglish
Pages (from-to)334-337
Number of pages4
Issue number3
Publication statusPublished - 2007 Mar 1

All Science Journal Classification (ASJC) codes

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

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