Sesamol down-regulates the lipopolysaccharide-induced inflammatory response by inhibiting nuclear factor-kappa B activation

Pei Yi Chu, Dur Zong Hsu, Pin Yen Hsu, Ming-Yi Liu

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We examined the effects of sesamol on the lipopolysaccharide (LPS)-induced inflammatory response. Sesamol inhibited serum tumor necrosis factor (TNF)-α, interleukin (IL)-1β and nitrite production in LPS-treated mice, and inhibited LPS-induced inducible nitric oxide synthase expression in mouse leukocytes. Sesamol also down-regulated TNF-α, IL-1β, and nitrite production as well as inducible nitric oxide synthase expression in LPS-treated RAW 264.7 cells. Further, sesamol inhibited LPS-induced nuclear factor (NF)-κB translocation and inhibitor (I)κB-α phosphorylation in RAW 264.7 cells. By inhibiting TNF-α, IL-1β, and nitrite levels, and interfering with the NFκB pathway, sesamol down-regulated the LPS-initiated inflammatory response.

Original languageEnglish
Pages (from-to)333-339
Number of pages7
JournalInnate Immunity
Volume16
Issue number5
DOIs
Publication statusPublished - 2010 Oct 1

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NF-kappa B
Lipopolysaccharides
Down-Regulation
Nitrites
Interleukin-1
Tumor Necrosis Factor-alpha
Nitric Oxide Synthase Type II
sesamol
Leukocytes
Phosphorylation
Serum

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Molecular Biology
  • Cell Biology
  • Infectious Diseases

Cite this

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abstract = "We examined the effects of sesamol on the lipopolysaccharide (LPS)-induced inflammatory response. Sesamol inhibited serum tumor necrosis factor (TNF)-α, interleukin (IL)-1β and nitrite production in LPS-treated mice, and inhibited LPS-induced inducible nitric oxide synthase expression in mouse leukocytes. Sesamol also down-regulated TNF-α, IL-1β, and nitrite production as well as inducible nitric oxide synthase expression in LPS-treated RAW 264.7 cells. Further, sesamol inhibited LPS-induced nuclear factor (NF)-κB translocation and inhibitor (I)κB-α phosphorylation in RAW 264.7 cells. By inhibiting TNF-α, IL-1β, and nitrite levels, and interfering with the NFκB pathway, sesamol down-regulated the LPS-initiated inflammatory response.",
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Sesamol down-regulates the lipopolysaccharide-induced inflammatory response by inhibiting nuclear factor-kappa B activation. / Chu, Pei Yi; Hsu, Dur Zong; Hsu, Pin Yen; Liu, Ming-Yi.

In: Innate Immunity, Vol. 16, No. 5, 01.10.2010, p. 333-339.

Research output: Contribution to journalArticle

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