Sesquiterpene esters of aristolochic acid from the root and stem of Aristolochia heterophylla

Tian-Shung Wu, Yu Yi Chan, Yann Lii Leu, Zong Tsi Chen

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18 Citations (Scopus)

Abstract

Three novel sesquiterpene esters of aristolochic acid, aristoloterpenate-II (2), -III (3), and-IV (4), together with known aristoloterpenate-I (1), were isolated and characterized from the root and stem of Aristolochia heterophylla. Their structures were elucidated by spectroscopic methods. The absolute configuration of these compounds at C-4' was determined as R by circular dichroic studies. These compounds showed cytotoxicity against hepatoma G2, 2, 2, 15 cells.

Original languageEnglish
Pages (from-to)415-418
Number of pages4
JournalJournal of Natural Products
Volume62
Issue number3
DOIs
Publication statusPublished - 1999 Jan 1

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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