Sesquiterpene esters of aristolochic acid from the root and stem of Aristolochia heterophylla

Tian-Shung Wu; Yu Yi Chan; Yann Lii Leu; Zong Tsi Chen

doi:10.1021/np980212y

Sesquiterpene esters of aristolochic acid from the root and stem of Aristolochia heterophylla

Tian-Shung Wu, Yu Yi Chan, Yann Lii Leu, Zong Tsi Chen

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Three novel sesquiterpene esters of aristolochic acid, aristoloterpenate-II (2), -III (3), and-IV (4), together with known aristoloterpenate-I (1), were isolated and characterized from the root and stem of Aristolochia heterophylla. Their structures were elucidated by spectroscopic methods. The absolute configuration of these compounds at C-4' was determined as R by circular dichroic studies. These compounds showed cytotoxicity against hepatoma G2, 2, 2, 15 cells.

Original language	English
Pages (from-to)	415-418
Number of pages	4
Journal	Journal of Natural Products
Volume	62
Issue number	3
DOIs	https://doi.org/10.1021/np980212y
Publication status	Published - 1999 Jan 1

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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abstract = "Three novel sesquiterpene esters of aristolochic acid, aristoloterpenate-II (2), -III (3), and-IV (4), together with known aristoloterpenate-I (1), were isolated and characterized from the root and stem of Aristolochia heterophylla. Their structures were elucidated by spectroscopic methods. The absolute configuration of these compounds at C-4' was determined as R by circular dichroic studies. These compounds showed cytotoxicity against hepatoma G2, 2, 2, 15 cells.",

author = "Tian-Shung Wu and Chan, {Yu Yi} and Leu, {Yann Lii} and Chen, {Zong Tsi}",

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T1 - Sesquiterpene esters of aristolochic acid from the root and stem of Aristolochia heterophylla

AU - Wu, Tian-Shung

AU - Chan, Yu Yi

AU - Leu, Yann Lii

AU - Chen, Zong Tsi

PY - 1999/1/1

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N2 - Three novel sesquiterpene esters of aristolochic acid, aristoloterpenate-II (2), -III (3), and-IV (4), together with known aristoloterpenate-I (1), were isolated and characterized from the root and stem of Aristolochia heterophylla. Their structures were elucidated by spectroscopic methods. The absolute configuration of these compounds at C-4' was determined as R by circular dichroic studies. These compounds showed cytotoxicity against hepatoma G2, 2, 2, 15 cells.

AB - Three novel sesquiterpene esters of aristolochic acid, aristoloterpenate-II (2), -III (3), and-IV (4), together with known aristoloterpenate-I (1), were isolated and characterized from the root and stem of Aristolochia heterophylla. Their structures were elucidated by spectroscopic methods. The absolute configuration of these compounds at C-4' was determined as R by circular dichroic studies. These compounds showed cytotoxicity against hepatoma G2, 2, 2, 15 cells.

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