TY - JOUR
T1 - Sesquiterpene pyridine alkaloids from Maytenus emarginata
T2 - Emarginatine-C and -D and cytotoxic emarginatine-E and emarginatinine
AU - Yao-Haur, Kuo
AU - Chung-Hsiung, Chen
AU - Ming-Lu, King
AU - Tian-Shung, Wu
AU - Kuo-Hsiung, Lee
N1 - Funding Information:
Acknowledgements-Thiisn vestigationw ass upportedb y a grantf rom theN ational CancerI nstitute( CA 17625o) f the U.S.A. awardedt o K. H. Lee and also was supported partly by a grantf rom the National ScienceC ouncil (81-0208-M077-502o) f Taiwan, R.O.C., awardedt o Y. H. Kuo. The authorsa lso thank ProfessorsS heng-TehL u and Ih-Sheng Chen, School of Pharmacy, Kaohsiung Medical College,R . 0. C., for collectingt heplant material, as well as Dr Chien-Chang Shen of the National ResearchIn stitute of ChineseM edicine for assistingt he measuremenotf 2D NMR spectra.
PY - 1994/2
Y1 - 1994/2
N2 - Four new sesquiterpene alkaloids, emarginatine-C, emarginatine-D, emarginatine-E and emarginatinine, were isolated from Maytenus emarginata. Emarginatine-E and emarginatinine showed cytotoxicity against human KB cells (ED50 = 2.5 and 2.1 μg ml-1, respectively). The structural determinations and activity relationships of these new compounds, and of emarginatine-A and emarginatine-B are discussed.
AB - Four new sesquiterpene alkaloids, emarginatine-C, emarginatine-D, emarginatine-E and emarginatinine, were isolated from Maytenus emarginata. Emarginatine-E and emarginatinine showed cytotoxicity against human KB cells (ED50 = 2.5 and 2.1 μg ml-1, respectively). The structural determinations and activity relationships of these new compounds, and of emarginatine-A and emarginatine-B are discussed.
UR - https://www.scopus.com/pages/publications/0028112719
UR - https://www.scopus.com/pages/publications/0028112719#tab=citedBy
U2 - 10.1016/S0031-9422(00)90610-1
DO - 10.1016/S0031-9422(00)90610-1
M3 - Article
AN - SCOPUS:0028112719
SN - 0031-9422
VL - 35
SP - 803
EP - 807
JO - Phytochemistry
JF - Phytochemistry
IS - 3
ER -