Shaping of innate immune response by fatty acid metabolite palmitate

Hong Tai Tzeng, I. Tsu Chyuan, Wei Yu Chen

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)

Abstract

Innate immune cells monitor invading pathogens and pose the first-line inflammatory response to coordinate with adaptive immunity for infection removal. Innate immunity also plays pivotal roles in injury-induced tissue remodeling and the maintenance of tissue homeostasis in physiological and pathological conditions. Lipid metabolites are emerging as the key players in the regulation of innate immune responses, and recent work has highlighted the importance of the lipid metabolite palmitate as an essential component in this regulation. Palmitate modulates innate immunity not only by regulating the activation of pattern recognition receptors in local innate immune cells, but also via coordinating immunological activity in inflammatory tissues. Moreover, protein palmitoylation controls various cellular physiological processes. Herein, we review the updated evidence that palmitate catabolism contributes to innate immune cell-mediated inflammatory processes that result in immunometabolic disorders.

Original languageEnglish
Article number1633
JournalCells
Volume8
Issue number12
DOIs
Publication statusPublished - 2019 Dec

All Science Journal Classification (ASJC) codes

  • General Medicine

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