Short-term celecoxib to regress long-term persistent gastric intestinal metaplasia after Helicobacter pylori eradication

Kuei Hsiang Hung, Hsiao Bai Yang, Hsiu-Chi Cheng, Jiunn Jong Wu, Bor-Shyang Sheu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background and Aim: The intestinal metaplasia (IM) has overexpressions of cyclooxygenase-2 (COX-2) and β-catenin. This pilot study assessed whether celecoxib, a selective COX-2 inhibitor, could regress IM that persisted long term after Helicobacter pylori eradication. Methods: Thirty-three patients with H. pylori eradication were enrolled in the present study due to the persistence of IM after a 3-year follow up. These patients received celecoxib 200 mg/day for 8 weeks, and were serially checked for levels of blood urea nitrogen and creatinine once per 2 weeks. After 8-week celecoxib treatment, IM regression was assessed by panendoscopy. The gastric specimens, taken before and after celecoxib, were immunochemically stained for COX-2 and β-catenin. Results: The intention-to-treat and per-protocol analyses to the rates of IM regression by 8-week celecoxib treatment were 24.2% (8/33) and 28.6% (8/28), respectively. All enrolled patients had no renal impairment. Even in the patients without total IM regression, mean IM scores in the antrum decreased after 8-week celecoxib treatment (P = 0.007). The patients with complete regression of IM after 8-week celecoxib treatment had a significantly lower COX-2 expression, but not β-catenin expression, at enrollment than those patients without IM regression (P = 0.031). Conclusion: Short-term celecoxib treatment can be safe and promising to regress long-term persistent IM after H. pylori eradication.

Original languageEnglish
Pages (from-to)48-53
Number of pages6
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume25
Issue number1
DOIs
Publication statusPublished - 2010 Jan 1

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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