Signaling from membrane receptors to tumor suppressor WW domain-containing oxidoreductase

Jean Yun Chang, Ruei Yu He, Hsin Ping Lin, Li-Jin Hsu, Feng Jie Lai, Qunying Hong, Shean Jen Chen, Nan-Shan Chang

Research output: Contribution to journalShort survey

43 Citations (Scopus)

Abstract

The family of WW domain-containing proteins contains over 2000 members. The small WW domain module is responsible, in part, for protein/protein binding interactions and signaling. Many of these proteins are located at the membrane/cytoskeleton area, where they act as adaptors to receive signals from the cell surface. In this review, we provide molecular insights regarding recent novel findings on signaling from the cell surface toward WW domain-containing oxidoreductase, known as WWOX, FOR or WOX1. More specifically, transforming growth factor beta 1 utilizes cell surface hyaluronidase Hyal-2 (hyaluronoglucosaminidase 2) as a cognate receptor for signaling with WWOX and Smad4 to control gene transcription, growth and death. Complement C1q alone, bypassing the activation of classical pathway, signals a novel event of apoptosis by inducing microvillus formation and WWOX activation. Deficiency in these signaling events appears to favorably support cancer growth.

Original languageEnglish
Pages (from-to)796-804
Number of pages9
JournalExperimental Biology and Medicine
Volume235
Issue number7
DOIs
Publication statusPublished - 2010 Jul 1

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Tumors
Oxidoreductases
Hyaluronoglucosaminidase
Membranes
Complement C1q
Neoplasms
Chemical activation
Growth
Microvilli
Cytoskeleton
Protein Binding
Transforming Growth Factor beta
Proteins
Signal Transduction
Transcription
Apoptosis
Genes
Protein Domains

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Chang, Jean Yun ; He, Ruei Yu ; Lin, Hsin Ping ; Hsu, Li-Jin ; Lai, Feng Jie ; Hong, Qunying ; Chen, Shean Jen ; Chang, Nan-Shan. / Signaling from membrane receptors to tumor suppressor WW domain-containing oxidoreductase. In: Experimental Biology and Medicine. 2010 ; Vol. 235, No. 7. pp. 796-804.
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Signaling from membrane receptors to tumor suppressor WW domain-containing oxidoreductase. / Chang, Jean Yun; He, Ruei Yu; Lin, Hsin Ping; Hsu, Li-Jin; Lai, Feng Jie; Hong, Qunying; Chen, Shean Jen; Chang, Nan-Shan.

In: Experimental Biology and Medicine, Vol. 235, No. 7, 01.07.2010, p. 796-804.

Research output: Contribution to journalShort survey

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