Significance of urinary tissue polypeptide specific antigen (TPS). Determination in patients with urothelial carcinoma

W. J. Yao, C. J. Chang, S. H. Chan, N. H. Chow, H. L. Cheng, T. S. Tzai, S. N. Lin

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16 Citations (Scopus)

Abstract

Tissue polypeptide specific antigen (TPS) is the M3 epitope of the tissue polypeptide antigen, and a specific epithelial proliferation marker. To examine the benefit of urine TPS (U-TPS) measurement in the diagnosis and classification of biological properties of transitional cell carcinoma (TCC), a radioimmunoassay of U-TPS was measured in patients with active TCC (n = 56), at tumor-free status (n = 36), with inflammatory urological disease (n = 44), and age-sex adjusted normal subjects (n = 75). Both neoplastic and inflammatory urological diseases had an increase in U-TPS levels (U/ gm creatinine) compared to normal individuals (p = 0.0005), while it normalized in tumor-free condition (p = 0.007). For patients with active TCC, a strong positive association was observed between U-TPS values and both histological grading (p = 0.05) and positive cytology (p = 0.05). U-TPS levels were significantly higher in the presence of nodal or systemic metastasis (p = 0.008 by ANOVA test). Measurement of U-TPS appeared to be an indicator of poor outcome for patients with bladder cancer (p = 0.05 by t test) for a mean follow-up of 26 months. The results indicate that determination of U-TPS can be a supplement in assessing the biological properties of TCC, and may be helpful in identifying patients who need meticulous peri-operative staging survey.

Original languageEnglish
Pages (from-to)2819-2823
Number of pages5
JournalAnticancer research
Volume15
Issue number6 B
Publication statusPublished - 1995

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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