Significance of urinary tissue polypeptide specific antigen (TPS). Determination in patients with urothelial carcinoma

Wei-Jen Yao, Chih-Jen Chang, Shih-Huang Chan, Nan-Haw Chow, Hong-Lin Cheng, T. S. Tzai, S. N. Lin

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Tissue polypeptide specific antigen (TPS) is the M3 epitope of the tissue polypeptide antigen, and a specific epithelial proliferation marker. To examine the benefit of urine TPS (U-TPS) measurement in the diagnosis and classification of biological properties of transitional cell carcinoma (TCC), a radioimmunoassay of U-TPS was measured in patients with active TCC (n = 56), at tumor-free status (n = 36), with inflammatory urological disease (n = 44), and age-sex adjusted normal subjects (n = 75). Both neoplastic and inflammatory urological diseases had an increase in U-TPS levels (U/ gm creatinine) compared to normal individuals (p = 0.0005), while it normalized in tumor-free condition (p = 0.007). For patients with active TCC, a strong positive association was observed between U-TPS values and both histological grading (p = 0.05) and positive cytology (p = 0.05). U-TPS levels were significantly higher in the presence of nodal or systemic metastasis (p = 0.008 by ANOVA test). Measurement of U-TPS appeared to be an indicator of poor outcome for patients with bladder cancer (p = 0.05 by t test) for a mean follow-up of 26 months. The results indicate that determination of U-TPS can be a supplement in assessing the biological properties of TCC, and may be helpful in identifying patients who need meticulous peri-operative staging survey.

Original languageEnglish
Pages (from-to)2819-2823
Number of pages5
JournalAnticancer research
Volume15
Issue number6 B
Publication statusPublished - 1995 Dec 1

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Significance of urinary tissue polypeptide specific antigen (TPS). Determination in patients with urothelial carcinoma'. Together they form a unique fingerprint.

Cite this