Silanization of Silicone Elastomer with Zwitterionic Surface Modifier for Robust Biocompatibility

Shiou Bang Yeh, Chien-Sheng Chen, Wen Yih Chen, Chia Yu Liu, Chun Jen Huang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Biofouling generally causes adverse effects to health, such as thrombosis, infection, and pathogenic calcification. Hydrophilic and charge-balanced surface is proved to provide an energy barrier serving as a strong repulsive force against the nonspecific absorption. Unfortunately, the state-ofart technology for silicone modification cannot provide a stable and effective coating for the long-term applications under complex conditions. In this study, we aim to modify the silicone surfaces with a zwitterionic surface ligand to resist nonspecific adsorption of protein, lipid and bacteria. We synthesized a silanized surface ligand conjugated with a head residue of zwitterionic sulfobetaine (SBSi) that bears positively charged quaternary amine and negatively charged sulfonate groups. The bacterial adhesion tests and protein fouling test revealed the excellent antifouling properties of modified silicones. For the real-world application, we modified commercially available silicone hydrogel contact lenses with developed zwitterionic ligands and showed their capability of anti-bacterial adhesion and anti protein fouling. In summary, the strategy of surface engineering in this work can be applied to not only contact lenses but other silicone-based medical devices in facile and effective fashion.

Original languageEnglish
Title of host publication1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering
EditorsShyh-Hau Wang, Fong-Chin Su, Ming-Long Yeh
PublisherSpringer Verlag
Pages1-4
Number of pages4
ISBN (Electronic)9783319122618
DOIs
Publication statusPublished - 2015 Jan 1
Event1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014 - Tainan, Taiwan
Duration: 2014 Oct 92014 Oct 12

Publication series

NameIFMBE Proceedings
Volume47
ISSN (Print)1680-0737

Other

Other1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014
CountryTaiwan
CityTainan
Period14-10-0914-10-12

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Silanization of Silicone Elastomer with Zwitterionic Surface Modifier for Robust Biocompatibility'. Together they form a unique fingerprint.

  • Cite this

    Yeh, S. B., Chen, C-S., Chen, W. Y., Liu, C. Y., & Huang, C. J. (2015). Silanization of Silicone Elastomer with Zwitterionic Surface Modifier for Robust Biocompatibility. In S-H. Wang, F-C. Su, & M-L. Yeh (Eds.), 1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering (pp. 1-4). (IFMBE Proceedings; Vol. 47). Springer Verlag. https://doi.org/10.1007/978-3-319-11128-5_1