Silicification of genipin-cross-linked polypeptide hydrogels toward biohybrid materials and mesoporous oxides

Jeng-Shiung Jan, Pei Shan Chen, Ping Lun Hsieh, Bo Yu Chen

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A simple and versatile approach is proposed to use cross-linked polypeptide hydrogels as templates for silica mineralization, allowing the synthesis of polypeptide-silica hybrid hydrogels and mesoporous silica (meso-SiO2) by subsequent calcination. The experimental data revealed that the cross-linked polypeptide hydrogels comprised of interconnected, membranous network served as templates for the high-fidelity transcription of silica replicas spanning from nanoscale to microscale, resulting in hybrid network comprised of interpenetrated polypeptide nanodomains and silica. The mechanical properties of these as-prepared polypeptide-silica hybrid hydrogels were found to vary with polypeptide chain length and composition. The synergy between cross-link, hydrophobic interaction, and silica deposition can lead to the enhancement of their mechanical properties. The polypeptide-silica hybrid hydrogel with polypeptide and silica content as low as 1.1 wt % can achieve 114 kN/m 2 of compressive strength. By removing the polypeptide nanodomains, mesoporous silicas with average pore sizes ranged between 2 nm and 6 nm can be obtained, depending on polypeptide chain length and composition. The polypeptide-silica hybrid hydrogels demonstrated good cell compatibility and can support cell attachment/proliferation. With the versatility of polymer chemistry and feasibility of amine-catalyzed sol-gel chemistry, the present method is facile for the synthesis of green nanocomposites and biomaterials.

Original languageEnglish
Pages (from-to)6865-6874
Number of pages10
JournalACS Applied Materials and Interfaces
Volume4
Issue number12
DOIs
Publication statusPublished - 2012 Dec 26

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Hydrogels
Polypeptides
Silicon Dioxide
Oxides
Silica
Peptides
Chain length
genipin
Compressive Strength
Nanocomposites
Mechanical properties
Hydrogel
Biocompatible Materials
Polymethyl Methacrylate
Transcription
Chemical analysis
Hydrophobic and Hydrophilic Interactions
Biomaterials
Calcination
Compressive strength

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

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abstract = "A simple and versatile approach is proposed to use cross-linked polypeptide hydrogels as templates for silica mineralization, allowing the synthesis of polypeptide-silica hybrid hydrogels and mesoporous silica (meso-SiO2) by subsequent calcination. The experimental data revealed that the cross-linked polypeptide hydrogels comprised of interconnected, membranous network served as templates for the high-fidelity transcription of silica replicas spanning from nanoscale to microscale, resulting in hybrid network comprised of interpenetrated polypeptide nanodomains and silica. The mechanical properties of these as-prepared polypeptide-silica hybrid hydrogels were found to vary with polypeptide chain length and composition. The synergy between cross-link, hydrophobic interaction, and silica deposition can lead to the enhancement of their mechanical properties. The polypeptide-silica hybrid hydrogel with polypeptide and silica content as low as 1.1 wt {\%} can achieve 114 kN/m 2 of compressive strength. By removing the polypeptide nanodomains, mesoporous silicas with average pore sizes ranged between 2 nm and 6 nm can be obtained, depending on polypeptide chain length and composition. The polypeptide-silica hybrid hydrogels demonstrated good cell compatibility and can support cell attachment/proliferation. With the versatility of polymer chemistry and feasibility of amine-catalyzed sol-gel chemistry, the present method is facile for the synthesis of green nanocomposites and biomaterials.",
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Silicification of genipin-cross-linked polypeptide hydrogels toward biohybrid materials and mesoporous oxides. / Jan, Jeng-Shiung; Chen, Pei Shan; Hsieh, Ping Lun; Chen, Bo Yu.

In: ACS Applied Materials and Interfaces, Vol. 4, No. 12, 26.12.2012, p. 6865-6874.

Research output: Contribution to journalArticle

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