Silver-Based SERS Pico-Molar Adenine Sensor

Yonhua Tzeng, Bo Yi Lin

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Adenine is an important molecule for biomedical and agricultural research and applications. The detection of low concentration adenine molecules is thus desirable. Surface-enhanced Raman scattering (SERS) is a promising label-free detection and fingerprinting technique for molecules of significance. A novel SERS sensor made of clusters of silver nanostructures deposited on copper bumps in valleys of an etched silicon substrate was previously reported to exhibit a low and reproducible detection limit for a 10−11 M neutral adenine aqueous solution. Reflection of laser illumination from the silicon surface surrounding a valley provides additional directions of laser excitation to adenine molecules adsorbing on a silver surface for the generation of enhanced SERS signal strength leading to a low detection limit. This paper further reports a concentration dependent shift of the ring-breathing mode SERS adenine peak towards 760 cm−1 with decreasing concentration and its pH-dependent SERS signal strength. For applications, where the pH value can vary, reproducible detection of 10−12 M adenine in a pH 9 aqueous solution is feasible, making the novel SERS structure a desirable pico-molar adenine sensor.

Original languageEnglish
Article number122
Issue number9
Publication statusPublished - 2020 Sep

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry


Dive into the research topics of 'Silver-Based SERS Pico-Molar Adenine Sensor'. Together they form a unique fingerprint.

Cite this