Single cell impedance analysis and electrical characterization in micro-fluidic device

Chia-Feng Liu, Jen Yu Jao, Ming Kun Chen, Ya Chun Chuang, Pin Chian Wu, Ling Sheng Jang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

We introduces a study of single cell in a microfluidic device constructed from polydimethylsiloxane (PDMS) using micro-electro-mechanical-system (MEMS) technology, used to measure the characterization of single cells under liquid medium. The microfluidic device combines a microfluidic structure to capture single cell level and a coplanar waveguide electrode inside a channel to measure the impedance of a single HeLa cell (human cervical epithelioid carcinoma). The electrical characterization of a single cell is demonstrated using a two-port vector network analyzer (VNA) in the frequency range of 1 MHz - 1 GHz. The validity of the electrical equivalent model in this study is asserted through measurements of cell impedance in phosphate buffer solution (PBS) liquid, as well as electrical simulations of a single HeLa cell experiment compared with measurements.

Original languageEnglish
Title of host publicationNEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems
Pages121-126
Number of pages6
DOIs
Publication statusPublished - 2011 Oct 4
Event6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2011 - Kaohsiung, Taiwan
Duration: 2011 Feb 202011 Feb 23

Publication series

NameNEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems

Other

Other6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2011
CountryTaiwan
CityKaohsiung
Period11-02-2011-02-23

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics

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