Single-cell trapping and impedance measurement utilizing dielectrophoresis in a parallel-plate microfluidic device

Nai Chin Chen, Chun Hong Chen, Ming Kun Chen, Ling Sheng Jang, Min Haw Wang

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

This paper integrates fluid manipulation, single-cell trapping, and single-cell impedance measurement into a parallel-plate chip. Liquid dielectophoresis (LDEP) and dielectrophoresis (DEP) are utilized to manipulate a sucrose solution and HeLa cells in a chip, respectively. The sucrose solution with HeLa cells is transported by LDEP. A cell is trapped by DEP and then its impedance is measured in an SU-8 cavity between measurement electrodes. Finite element analysis (FEA) is used to optimize the microstructure of the SU-8 cavity.

Original languageEnglish
Pages (from-to)570-577
Number of pages8
JournalSensors and Actuators, B: Chemical
Volume190
DOIs
Publication statusPublished - 2014 Jan 1

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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