Single-Photon-Emission Computed Tomography Studies with Dopamine and Serotonin Transporters in Opioid Users

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Opioid dependence is harmful to individuals and society as a whole. Dopamine has been proposed to be involved in the mechanism associated with opioid dependence. Meanwhile, another monoamine neurotransmitter, serotonin, might also play a role. In this chapter, we review the findings from neuroimaging studies that used single-photon-emission computed tomography. In agreement with the dopamine hypothesis of addiction, the findings indicated a 10-30% reduction in dopamine transporter availability among those with opioid dependence. The evidence also implied a certain level of recovery after treatment. A similar effect was also found for serotonin; however, evidence is very scarce. The association between serotonergic activity and treatment outcome is controversial. We discuss the theoretical and clinical implications at the end of this chapter.

Original languageEnglish
Title of host publicationFoundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids
PublisherElsevier Inc.
Pages966-973
Number of pages8
Volume1
ISBN (Electronic)9780128003763
ISBN (Print)9780128002131
DOIs
Publication statusPublished - 2016 Mar 23

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Serotonin Plasma Membrane Transport Proteins
Dopamine Plasma Membrane Transport Proteins
Single-Photon Emission-Computed Tomography
Opioid Analgesics
Dopamine
Serotonin
Neuroimaging
Neurotransmitter Agents

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lin, S. H., Chen, K-C., & Yang, Y-K. (2016). Single-Photon-Emission Computed Tomography Studies with Dopamine and Serotonin Transporters in Opioid Users. In Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids (Vol. 1, pp. 966-973). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800213-1.00090-0
Lin, Shih Hsien ; Chen, Kao-Ching ; Yang, Yen-Kuang. / Single-Photon-Emission Computed Tomography Studies with Dopamine and Serotonin Transporters in Opioid Users. Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids. Vol. 1 Elsevier Inc., 2016. pp. 966-973
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Lin, SH, Chen, K-C & Yang, Y-K 2016, Single-Photon-Emission Computed Tomography Studies with Dopamine and Serotonin Transporters in Opioid Users. in Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids. vol. 1, Elsevier Inc., pp. 966-973. https://doi.org/10.1016/B978-0-12-800213-1.00090-0

Single-Photon-Emission Computed Tomography Studies with Dopamine and Serotonin Transporters in Opioid Users. / Lin, Shih Hsien; Chen, Kao-Ching; Yang, Yen-Kuang.

Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids. Vol. 1 Elsevier Inc., 2016. p. 966-973.

Research output: Chapter in Book/Report/Conference proceedingChapter

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AB - Opioid dependence is harmful to individuals and society as a whole. Dopamine has been proposed to be involved in the mechanism associated with opioid dependence. Meanwhile, another monoamine neurotransmitter, serotonin, might also play a role. In this chapter, we review the findings from neuroimaging studies that used single-photon-emission computed tomography. In agreement with the dopamine hypothesis of addiction, the findings indicated a 10-30% reduction in dopamine transporter availability among those with opioid dependence. The evidence also implied a certain level of recovery after treatment. A similar effect was also found for serotonin; however, evidence is very scarce. The association between serotonergic activity and treatment outcome is controversial. We discuss the theoretical and clinical implications at the end of this chapter.

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Lin SH, Chen K-C, Yang Y-K. Single-Photon-Emission Computed Tomography Studies with Dopamine and Serotonin Transporters in Opioid Users. In Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids. Vol. 1. Elsevier Inc. 2016. p. 966-973 https://doi.org/10.1016/B978-0-12-800213-1.00090-0