Single photon emission computerized tomography in children with developmental language disorder - A preliminary report

Bi-Fang Lee, Pinchen Yang, Yuh Jyh Jong, Hsiu Yi Hsu, Cheng Chung Chen

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Developmental language disorder (DLD) is a diagnosis given to a nonautistic child who has inadequate language acquisition despite adequate hearing, sensorimotor, and cognitive skills. We used high-resolution single photon emission computerized tomography (SPECT) with labeled technetium-99m-D, L-hexamethyl-propylene amine oxime (99mTc-HMPAO) to measure regional cerebral blood flow (rCBF) in 11 children with DLD. Their mean age was 5 years 10 months (range, 4 yr 2 mo to 10 yr 9 mo) and mean nonverbal IQ was 107 (range, 82-137). When inter-hemispheric flow discrepancy was defined as a bilateral rCBF difference of more than 10%, 10 children (90.9%) had discrepant blood flow. Temporal lobes were involved in all 10 children: lateral-temporal in five, medial-temporal in four, and mesialtemporal in four. Though the study was small and the results are preliminary, results suggest that DLD may be a consequence of an underlying neurobiologic problem in areas of the brain known to be involved with language.

Original languageEnglish
Pages (from-to)373-378
Number of pages6
JournalKaohsiung Journal of Medical Sciences
Volume18
Issue number8
Publication statusPublished - 2002 Aug 1

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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