Size selectivity and trapping efficiency of single-cells with a hydrodynamic well in a microfluidic device

Cheng Ming Lin, Chan Chia Tseng, Ting-Yuan Tu, Chen Lin Chen, Andrew M. Wo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper reports size select ivity of single cells and trapping performance of a hydrodynamic well (HW) in a micro-fluidic device. HW can trap single cells non-invasively with little dependence on cell and/or medium properties. Computational results reveal the pressure gradient and a background flow can enhance cell trapping. Cell size selection was characterized and shown a typical range of single cell size can be trapped with a high success trapping performance of 98%. The maximum number of trapped cell is depended on the length of plate's edge and cell's dimension. This noninvasive trapping platform using the hydrodynamic well sho uld be useful for variety of cellular microfluidic applications.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages1613-1615
Number of pages3
Publication statusPublished - 2010 Dec 1
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: 2010 Oct 32010 Oct 7

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume3

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10-10-0310-10-07

Fingerprint

Microfluidics
Hydrodynamics
Fluidic devices
Pressure gradient

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

Cite this

Lin, C. M., Tseng, C. C., Tu, T-Y., Chen, C. L., & Wo, A. M. (2010). Size selectivity and trapping efficiency of single-cells with a hydrodynamic well in a microfluidic device. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (pp. 1613-1615). (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 3).
Lin, Cheng Ming ; Tseng, Chan Chia ; Tu, Ting-Yuan ; Chen, Chen Lin ; Wo, Andrew M. / Size selectivity and trapping efficiency of single-cells with a hydrodynamic well in a microfluidic device. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 2010. pp. 1613-1615 (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010).
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abstract = "This paper reports size select ivity of single cells and trapping performance of a hydrodynamic well (HW) in a micro-fluidic device. HW can trap single cells non-invasively with little dependence on cell and/or medium properties. Computational results reveal the pressure gradient and a background flow can enhance cell trapping. Cell size selection was characterized and shown a typical range of single cell size can be trapped with a high success trapping performance of 98{\%}. The maximum number of trapped cell is depended on the length of plate's edge and cell's dimension. This noninvasive trapping platform using the hydrodynamic well sho uld be useful for variety of cellular microfluidic applications.",
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Lin, CM, Tseng, CC, Tu, T-Y, Chen, CL & Wo, AM 2010, Size selectivity and trapping efficiency of single-cells with a hydrodynamic well in a microfluidic device. in 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010, vol. 3, pp. 1613-1615, 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010, Groningen, Netherlands, 10-10-03.

Size selectivity and trapping efficiency of single-cells with a hydrodynamic well in a microfluidic device. / Lin, Cheng Ming; Tseng, Chan Chia; Tu, Ting-Yuan; Chen, Chen Lin; Wo, Andrew M.

14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 2010. p. 1613-1615 (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 3).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - This paper reports size select ivity of single cells and trapping performance of a hydrodynamic well (HW) in a micro-fluidic device. HW can trap single cells non-invasively with little dependence on cell and/or medium properties. Computational results reveal the pressure gradient and a background flow can enhance cell trapping. Cell size selection was characterized and shown a typical range of single cell size can be trapped with a high success trapping performance of 98%. The maximum number of trapped cell is depended on the length of plate's edge and cell's dimension. This noninvasive trapping platform using the hydrodynamic well sho uld be useful for variety of cellular microfluidic applications.

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Lin CM, Tseng CC, Tu T-Y, Chen CL, Wo AM. Size selectivity and trapping efficiency of single-cells with a hydrodynamic well in a microfluidic device. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 2010. p. 1613-1615. (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010).