Two velocity profiles of saccades with different shapes may still have similar main sequence relationship. Therefore, skewness was recently proposed as a valuable parameter in characterizing the saccade dynamics to complement the deficiency of main sequence relationship. Eleven patients with mild to moderate Parkinson's disease (PD) and eight age-matched normal subjects were evaluated in this study. Skewness was estimated from shape parameter obtained by applying gamma functions to the velocity profiles. As compared to the normal age-matched controls, the results show antisaccade skewness is significantly increased for the patient, while prosaccade skewness and peak velocity of both prosaccade and antisaccade paradigms are not significantly different. This implies skewness of the antisaccade velocity profiles can be used as an efficient quantitative parameter in differentiating the PD patients from the normal age-matched controls.
|Number of pages||8|
|Journal||Biomedical Engineering - Applications, Basis and Communications|
|Publication status||Published - 1999 Jun 25|
All Science Journal Classification (ASJC) codes
- Biomedical Engineering